Gene Expression Literature Summary
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Assay
Age
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Western blot
Postnatal
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| Rps6 ribosomal protein S6 (Synonyms: S6R) | |
| Results | Reference |
| 1* | J:148991 Barkic M, Crnomarkovic S, Grabusic K, Bogetic I, Panic L, Tamarut S, Cokaric M, Jeric I, Vidak S, Volarevic S, The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival. Mol Cell Biol. 2009 May;29(10):2489-504 |
| 1 | J:208766 Chen J, Tu X, Esen E, Joeng KS, Lin C, Arbeit JM, Ruegg MA, Hall MN, Ma L, Long F, WNT7B promotes bone formation in part through mTORC1. PLoS Genet. 2014 Jan;10(1):e1004145 |
| 1 | J:266104 Choi JH, Jo HS, Lim S, Kim HT, Lee KW, Moon KH, Ha T, Kwak SS, Kim Y, Lee EJ, Joe CO, Kim JW, mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502 |
| 1 | J:332969 Comerford SA, Hinnant EA, Chen Y, Hammer RE, Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent. PLoS Genet. 2023 Jan;19(1):e1010595 |
| 1 | J:246667 Cortez-Toledo O, Schnair C, Sangngern P, Metzger D, Chao LC, Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. PLoS One. 2017;12(2):e0171268 |
| 1 | J:178952 Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q, Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM, Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell. 2011 Nov 15;20(5):635-48 |
| 1 | J:248325 Figlia G, Norrmen C, Pereira JA, Gerber D, Suter U, Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. Elife. 2017 Sep 07;6:e29241 |
| 1 | J:333283 Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH, Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Kidney Int. 2022 Jul;102(1):108-120 |
| 1* | J:154667 Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM, Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7 |
| 1 | J:139866 Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH, Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell. 2007 Oct 11;1(4):443-57 |
| 1 | J:220518 Hu H, Matter ML, Issa-Jahns L, Jijiwa M, Kraemer N, Musante L, de la Vega M, Ninnemann O, Schindler D, Damatova N, Eirich K, Sifringer M, Schrotter S, Eickholt BJ, van den Heuvel L, Casamina C, Stoltenburg-Didinger G, Ropers HH, Wienker TF, Hubner C, Kaindl AM, Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness. Ann Clin Transl Neurol. 2014 Dec;1(12):1024-35 |
| 1* | J:161878 Hudon V, Sabourin S, Dydensborg AB, Kottis V, Ghazi A, Paquet M, Crosby K, Pomerleau V, Uetani N, Pause A, Renal tumour suppressor function of the Birt-Hogg-Dube syndrome gene product folliculin. J Med Genet. 2010 Mar;47(3):182-9 |
| 1 | J:276614 Hwang SH, Somatilaka BN, Badgandi H, Palicharla VR, Walker R, Shelton JM, Qian F, Mukhopadhyay S, Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia. Curr Biol. 2019 Mar 4;29(5):790-802.e5 |
| 1 | J:226834 Jones I, Hagglund AC, Tornqvist G, Nord C, Ahlgren U, Carlsson L, A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development. Dis Model Mech. 2015 Dec 1;8(12):1517-29 |
| 1 | J:297745 Kapur M, Ganguly A, Nagy G, Adamson SI, Chuang JH, Frankel WN, Ackerman SL, Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility. Neuron. 2020 Oct 14;108(1):193-208.e9 |
| 1 | J:211789 Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A, Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014 Jun 12;7(5):1626-39 |
| 1 | J:228845 Kim E, Wang Y, Kim SJ, Bornhorst M, Jecrois ES, Anthony TE, Wang C, Li YE, Guan JL, Murphy GG, Zhu Y, Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1. Elife. 2014;3 |
| 1 | J:335218 Knaus LS, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M, Schwarz LA, Gorkiewicz S, Amberg N, Pauler FM, Knittl-Frank C, Tassinari M, Maulide N, Rulicke T, Menche J, Hippenmeyer S, Novarino G, Large neutral amino acid levels tune perinatal neuronal excitability and survival. Cell. 2023 Apr 27;186(9):1950-1967.e25 |
| 1 | J:219284 La Rocca G, Olejniczak SH, Gonzalez AJ, Briskin D, Vidigal JA, Spraggon L, DeMatteo RG, Radler MR, Lindsten T, Ventura A, Tuschl T, Leslie CS, Thompson CB, In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):767-72 |
| 1 | J:329967 Li H, Li C, Zhai W, Zhang X, Li L, Wu B, Yu B, Zhang P, Li J, Cui CP, Zhang L, Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival. Cell Rep. 2022 Oct 4;41(1):111435 |
| 1* | J:268425 Li Z, Parlakian A, Coletti D, Alonso-Martin S, Hourde C, Joanne P, Gao-Li J, Blanc J, Ferry A, Paulin D, Xue Z, Agbulut O, Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy. J Cell Sci. 2014 Nov 1;127(Pt 21):4589-601 |
| 1 | J:314167 Lim S, Kim YJ, Park S, Choi JH, Sung YH, Nishimori K, Kozmik Z, Lee HW, Kim JW, mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079 |
| 1 | J:238888 Luo W, Zhao X, Jin H, Tao L, Zhu J, Wang H, Hemmings BA, Yang Z, Akt1 signaling coordinates BMP signaling and beta-catenin activity to regulate second heart field progenitor development. Development. 2015 Feb 15;142(4):732-42 |
| 1 | J:177840 Magri L, Cambiaghi M, Cominelli M, Alfaro-Cervello C, Cursi M, Pala M, Bulfone A, Garcia-Verdugo JM, Leocani L, Minicucci F, Poliani PL, Galli R, Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions. Cell Stem Cell. 2011 Nov 4;9(5):447-62 |
| 1 | J:201333 Magri L, Cominelli M, Cambiaghi M, Cursi M, Leocani L, Minicucci F, Poliani PL, Galli R, Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models. Dis Model Mech. 2013 Sep-Oct;6(5):1185-97 |
| 1 | J:232899 Moon UY, Park JY, Park R, Cho JY, Hughes LJ, McKenna J 3rd, Goetzl L, Cho SH, Crino PB, Gambello MJ, Kim S, Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex. Cell Rep. 2015 Aug 11;12(6):965-78 |
| 1* | J:332746 Navas-Perez E, Vicente-Garcia C, Mirra S, Burguera D, Fernandez-Castillo N, Ferran JL, Lopez-Mayorga M, Alaiz-Noya M, Suarez-Pereira I, Anton-Galindo E, Ulloa F, Herrera-Ubeda C, Cusco P, Falcon-Moya R, Rodriguez-Moreno A, D'Aniello S, Cormand B, Marfany G, Soriano E, Carrion AM, Carvajal JJ, Garcia-Fernandez J, Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions. Genome Biol. 2020 Oct 26;21(1):267 |
| 1* | J:249893 Nguyen HT, Hinman MN, Guo X, Sharma A, Arakawa H, Luo G, Lou H, Neurofibromatosis type 1 alternative splicing is a key regulator of Ras/ERK signaling and learning behaviors in mice. Hum Mol Genet. 2017 Oct 01;26(19):3797-3807 |
| 1 | J:342544 Radzishevsky I, Odeh M, Bodner O, Zubedat S, Shaulov L, Litvak M, Esaki K, Yoshikawa T, Agranovich B, Li WH, Radzishevsky A, Gottlieb E, Avital A, Wolosker H, Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2302780120 |
| 1 | J:269511 Roy A, Skibo J, Kalume F, Ni J, Rankin S, Lu Y, Dobyns WB, Mills GB, Zhao JJ, Baker SJ, Millen KJ, Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy. Elife. 2015 Dec 3;4:e12703 |
| 1 | J:325114 Serra I, Stravs A, Osorio C, Oyaga MR, Schonewille M, Tudorache C, Badura A, Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum. Front Mol Neurosci. 2022;15:831687 |
| 1 | J:344838 Sharma S, Kajjo S, Harra Z, Hasaj B, Delisle V, Ray D, Gutierrez RL, Carrier I, Kleinman C, Morris Q, Hughes TR, McInnes R, Fabian MR, Uncovering a mammalian neural-specific poly(A) binding protein with unique properties. Genes Dev. 2023 Aug 1;37(15-16):760-777 |
| 1 | J:106937 Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H, Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006 Apr;26(7):2772-81 |
| 1 | J:332498 Tran Nguyen Truc L, Matsuda S, Takenouchi A, Tran Thuy Huong Q, Kotani Y, Miyazaki T, Kanda H, Yoshizawa K, Tsukaguchi H, Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons. Sci Rep. 2023 Jan 10;13(1):508 |
| 1 | J:268904 Tripathy R, Leca I, van Dijk T, Weiss J, van Bon BW, Sergaki MC, Gstrein T, Breuss M, Tian G, Bahi-Buisson N, Paciorkowski AR, Pagnamenta AT, Wenninger-Weinzierl A, Martinez-Reza MF, Landler L, Lise S, Taylor JC, Terrone G, Vitiello G, Del Giudice E, Brunetti-Pierri N, D'Amico A, Reymond A, Voisin N, Bernstein JA, Farrelly E, Kini U, Leonard TA, Valence S, Burglen L, Armstrong L, Hiatt SM, Cooper GM, Aldinger KA, Dobyns WB, Mirzaa G, Pierson TM, Baas F, Chelly J, Cowan NJ, Keays DA, Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations. Neuron. 2018 Dec 19;100(6):1354-1368.e5 |
| 1* | J:147897 Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi-Miyagawa S, Nakano T, Lin H, MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem. 2009 Mar 6;284(10):6507-19 |
| 1 | J:239679 Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, Gonzalez-Billalabeitia E, Hung MC, Song SJ, Song MS, A UBE2O-AMPKalpha2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017 Feb 13;31(2):208-224 |
| 1 | J:326953 Wu X, Sosunov AA, Lado W, Teoh JJ, Ham A, Li H, Al-Dalahmah O, Gill BJA, Arancio O, Schevon CA, Frankel WN, McKhann GM 2nd, Sulzer D, Goldman JE, Tang G, Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex. Cell Rep. 2022 Jul 19;40(3):111085 |
| 1 | J:320720 Yu Z, Yang Z, Ren G, Wang Y, Luo X, Zhu F, Yu S, Jia L, Chen M, Worley PF, Xiao B, GATOR2 complex-mediated amino acid signaling regulates brain myelination. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2110917119 |
| 1* | J:138573 Yurttas P, Vitale AM, Fitzhenry RJ, Cohen-Gould L, Wu W, Gossen JA, Coonrod SA, Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo. Development. 2008 Aug;135(15):2627-36 |
| 1* | J:304555 Zamfirescu RC, Day ML, Morris MB, mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition. Am J Physiol Cell Physiol. 2021 Jan 1;320(1):C30-C44 |
| 1 | J:306954 Zecchini S, Giovarelli M, Perrotta C, Morisi F, Touvier T, Di Renzo I, Moscheni C, Bassi MT, Cervia D, Sandri M, Clementi E, De Palma C, Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism. Autophagy. 2019 Jan;15(1):58-77 |
| 1 | J:168571 Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B, Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011 Jan 18;20(1):97-108 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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