Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hif1a  hypoxia inducible factor 1, alpha subunit   (Synonyms: bHLHe78, HIF1alpha, HIF-1alpha, MOP1)
Results	Reference
1*	J:180152 Bridges JP, Lin S, Ikegami M, Shannon JM, Conditional hypoxia inducible factor-1alpha induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol. 2012 Feb 1;362(1):24-41
1	J:314936 Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL, Stevens HE, Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Transl Psychiatry. 2021 Jan 28;11(1):79
1*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:316639 He MY, Wang G, Han SS, Jin Y, Li H, Wu X, Ma ZL, Cheng X, Tang X, Yang X, Liu GS, Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta. Open Biol. 2016 Jul;6(7)
1	J:253786 Hu X, Li J, Zhang Q, Zheng L, Wang G, Zhang X, Zhang J, Gu Q, Ye Y, Guo SW, Yang X, Wang L, Phosphoinositide 3-Kinase (PI3K) Subunit p110delta Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse. Sci Rep. 2016 Jun 16;6:28201
1	J:162597 Hyvarinen J, Hassinen IE, Sormunen R, Maki JM, Kivirikko KI, Koivunen P, Myllyharju J, Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem. 2010 Apr 30;285(18):13646-57
1	J:211963 Kawakami T, Yoshimi M, Kadota Y, Inoue M, Sato M, Suzuki S, Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):134-44
1	J:321522 Kirschner KM, Kelterborn S, Stehr H, Penzlin JLT, Jacobi CLJ, Endesfelder S, Sieg M, Kruppa J, Dame C, Sciesielski LK, Adaptation of the Oxygen Sensing System during Lung Development. Oxid Med Cell Longev. 2022;2022:9714669
1	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
1	J:137720 Kubota Y, Hirashima M, Kishi K, Stewart CL, Suda T, Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest. 2008 Jul;118(7):2393-403
1	J:185536 Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW, Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development. 2012 Jul;139(13):2340-50
1	J:232444 Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z, Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41
1	J:314167 Lim S, Kim YJ, Park S, Choi JH, Sung YH, Nishimori K, Kozmik Z, Lee HW, Kim JW, mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079
1	J:258670 Mahany EB, Han X, Borges BC, da Silveira Cruz-Machado S, Allen SJ, Garcia-Galiano D, Hoenerhoff MJ, Bellefontaine NH, Elias CF, Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733
1*	J:265444 Matsumoto L, Hirota Y, Saito-Fujita T, Takeda N, Tanaka T, Hiraoka T, Akaeda S, Fujita H, Shimizu-Hirota R, Igaue S, Matsuo M, Haraguchi H, Saito-Kanatani M, Fujii T, Osuga Y, HIF2alpha in the uterine stroma permits embryo invasion and luminal epithelium detachment. J Clin Invest. 2018 Jul 2;128(7):3186-3197
1*	J:74121 Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ, Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713-20
1	J:201437 Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ, Matzuk MM, BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest. 2013 Jun 3;123(6):2539-50
1*	J:166841 Nordstrand LM, Svard J, Larsen E, Nilsen A, Ougland R, Furu K, Lien GF, Rognes T, Namekawa SH, Lee JT, Klungland A, Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS One. 2010;5(11):e13827
1	J:123628 Papadaki C, Alexiou M, Cecena G, Verykokakis M, Bilitou A, Cross JC, Oshima RG, Mavrothalassitis G, Transcriptional repressor erf determines extraembryonic ectoderm differentiation. Mol Cell Biol. 2007 Jul;27(14):5201-13
1	J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115
1	J:208938 Reinert RB, Brissova M, Shostak A, Pan FC, Poffenberger G, Cai Q, Hundemer GL, Kantz J, Thompson CS, Dai C, McGuinness OP, Powers AC, Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes. 2013 Dec;62(12):4154-64
1	J:270627 Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P, Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Skelet Muscle. 2016;6(1):30
1	J:253433 Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y, Allsopp RC, Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle. PLoS One. 2016;11(5):e0154309
1	J:232285 Tibboel J, Groenman FA, Selvaratnam J, Wang J, Tseu I, Huang Z, Caniggia I, Luo D, van Tuyl M, Ackerley C, de Jongste JC, Tibboel D, Post M, Hypoxia-inducible factor-1 stimulates postnatal lung development but does not prevent O2-induced alveolar injury. Am J Respir Cell Mol Biol. 2015 Apr;52(4):448-58
1*	J:47434 Wenger RH, Rolfs A, Spielmann P, Zimmermann DR, Gassmann M, Mouse hypoxia-inducible factor-1alpha is encoded by two different mRNA isoforms: expression from a tissue-specific and a housekeeping-type promoter. Blood. 1998 May 1;91(9):3471-80
1	J:243365 Williams CJ, Chu A, Jefferson WN, Casero D, Sudhakar D, Khurana N, Hogue CP, Aryasomayajula C, Patel P, Sullivan P, Padilla-Banks E, Mohandessi S, Janzen C, Wadehra M, Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. J Pathol. 2017 Jun;242(2):246-259
1	J:281275 Yao Q, Khan MP, Merceron C, LaGory EL, Tata Z, Mangiavini L, Hu J, Vemulapalli K, Chandel NS, Giaccia AJ, Schipani E, Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate. Dev Cell. 2019 Jun 3;49(5):748-763.e7
1	J:296376 Zhao H, Narasimhan P, Kalish F, Wong RJ, Stevenson DK, Dysregulation of hypoxia-inducible factor-1alpha (Hif1alpha) expression in the Hmox1-deficient placenta. Placenta. 2020 Sep 15;99:108-116
1	J:342401 Zhao H, Wong RJ, Stevenson DK, The placental vasculature is affected by changes in gene expression and glycogen-rich cells in a diet-induced obesity mouse model. PLoS One. 2023;18(11):e0294185
1	J:228857 Zhu X, Wang F, Zhao Y, Yang P, Chen J, Sun H, Liu L, Li W, Pan L, Guo Y, Kou Z, Zhang Y, Zhou C, He J, Zhang X, Li J, Han W, Li J, Liu G, Gao S, Yang Z, A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. PLoS Genet. 2014 Oct;10(10):e1004589