Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdkn2a  cyclin dependent kinase inhibitor 2A   (Synonyms: Arf, ARF-INK4a, Ink4a/Arf, INK4a-ARF, MTS1, p16, p16INK4a, p19ARF, p19, Pctr1)
Results	Reference
1	J:167536 Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G, Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010 Nov 5;7(5):606-17
1*	J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
1	J:252052 Bassiouni M, Dos Santos A, Avci HX, Lowenheim H, Muller M, Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro. PLoS One. 2016;11(10):e0164579
1	J:261043 Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U, Impaired proteoglycan glycosylation, elevated TGF-beta signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar;14(3):e1007242
1	J:144496 Chatoo W, Abdouh M, David J, Champagne MP, Ferreira J, Rodier F, Bernier G, The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci. 2009 Jan 14;29(2):529-42
1	J:332969 Comerford SA, Hinnant EA, Chen Y, Hammer RE, Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent. PLoS Genet. 2023 Jan;19(1):e1010595
1*	J:149526 Freeman-Anderson NE, Zheng Y, McCalla-Martin AC, Treanor LM, Zhao YD, Garfin PM, He TC, Mary MN, Thornton JD, Anderson C, Gibbons M, Saab R, Baumer SH, Cunningham JM, Skapek SX, Expression of the Arf tumor suppressor gene is controlled by Tgf{beta}2 during development. Development. 2009 Jun;136(12):2081-9
1	J:305202 Gualtieri A, Kyprianou N, Gregory LC, Vignola ML, Nicholson JG, Tan R, Inoue SI, Scagliotti V, Casado P, Blackburn J, Abollo-Jimenez F, Marinelli E, Besser REJ, Hogler W, Karen Temple I, Davies JH, Gagunashvili A, Robinson ICAF, Camper SA, Davis SW, Cutillas PR, Gevers EF, Aoki Y, Dattani MT, Gaston-Massuet C, Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans. Nat Commun. 2021 Apr 1;12(1):2028
1*	J:201153 Hamard PJ, Barthelery N, Hogstad B, Mungamuri SK, Tonnessen CA, Carvajal LA, Senturk E, Gillespie V, Aaronson SA, Merad M, Manfredi JJ, The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev. 2013 Sep 1;27(17):1868-85
1*	J:93610 Harrelson Z, Kelly RG, Goldin SN, Gibson-Brown JJ, Bollag RJ, Silver LM, Papaioannou VE, Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development. 2004 Oct;131(20):5041-52
1	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1	J:242258 Iida A, Iwagawa T, Baba Y, Satoh S, Mochizuki Y, Nakauchi H, Furukawa T, Koseki H, Murakami A, Watanabe S, Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation. Dev Neurobiol. 2015 Sep;75(9):947-60
1	J:171612 Juan AH, Derfoul A, Feng X, Ryall JG, Dell'orso S, Pasut A, Zare H, Simone JM, Rudnicki MA, Sartorelli V, Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells. Genes Dev. 2011 Apr 15;25(8):789-94
1	J:335074 Kuzelova A, Dupacova N, Antosova B, Sunny SS, Kozmik Z Jr, Paces J, Skoultchi AI, Stopka T, Kozmik Z, Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Cells. 2023 Mar 28;12(7)
1	J:255932 Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J, Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma. Nat Commun. 2017 Nov 28;8(1):1819
1*	J:276637 Matsuyama M, Tanaka H, Inoko A, Goto H, Yonemura S, Kobori K, Hayashi Y, Kondo E, Itohara S, Izawa I, Inagaki M, Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells. J Biol Chem. 2013 Dec 13;288(50):35626-35
1	J:183999 Ouseph MM, Li J, Chen HZ, Pecot T, Wenzel P, Thompson JC, Comstock G, Chokshi V, Byrne M, Forde B, Chong JL, Huang K, Machiraju R, de Bruin A, Leone G, Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62
1	J:239946 Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV, Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing beta-cells to a delta-like fate and reveals a facultative proliferative capacity in aged beta-cells. Development. 2015 Nov 01;142(21):3637-48
1	J:89729 Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF, Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003 May 15;423(6937):302-5
1	J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115
1	J:189320 Ramkumar C, Kong Y, Cui H, Hao S, Jones SN, Gerstein RM, Zhang H, Smurf2 regulates the senescence response and suppresses tumorigenesis in mice. Cancer Res. 2012 Jun 1;72(11):2714-9
1	J:321171 Safwan-Zaiter H, Wagner N, Michiels JF, Wagner KD, Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging. Cells. 2022 Feb 4;11(3)
1	J:162790 Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S, PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol. 2010 Aug;30(15):3864-74
1*	J:280399 Singh A, Mia MM, Cibi DM, Arya AK, Bhadada SK, Singh MK, Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice. J Biol Chem. 2019 May 24;294(21):8336-8347
1	J:216065 Xu CR, Li LC, Donahue G, Ying L, Zhang YW, Gadue P, Zaret KS, Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification. EMBO J. 2014 Oct 1;33(19):2157-70
1	J:225537 Zhang J, Taylor RJ, La Torre A, Wilken MS, Cox KE, Reh TA, Vetter ML, Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation. Dev Biol. 2015 Jul 15;403(2):128-38
1	J:211548 Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D, Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20;129(2):303-17
1	J:41862 Zindy F, Quelle DE, Roussel MF, Sherr CJ, Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene. 1997 Jul 10;15(2):203-11