Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pdx1  pancreatic and duodenal homeobox 1   (Synonyms: IDX-1, Ipf1, IPF-1, Mody4, pdx-1, STF-1)
Results	Reference
1	J:308553 Akerman I, Maestro MA, De Franco E, Grau V, Flanagan S, Garcia-Hurtado J, Mittler G, Ravassard P, Piemonti L, Ellard S, Hattersley AT, Ferrer J, Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene. Cell Rep. 2021 Apr 13;35(2):108981
1	J:309174 Bohuslavova R, Smolik O, Malfatti J, Berkova Z, Novakova Z, Saudek F, Pavlinkova G, NEUROD1 Is Required for the Early alpha and beta Endocrine Differentiation in the Pancreas. Int J Mol Sci. 2021 Jun 23;22(13)
1	J:106993 Briancon N, Weiss MC, In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J. 2006 Mar 22;25(6):1253-62
1	J:200985 Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M, Retinoblastoma tumor suppressor protein in pancreatic progenitors controls alpha- and beta-cell fate. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8
1	J:129103 Chao CS, Loomis ZL, Lee JE, Sussel L, Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007 Dec 15;312(2):523-32
1	J:235909 Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT Jr, Powers AC, Gu G, Stein R, The MAFB transcription factor impacts islet alpha-cell function in rodents and represents a unique signature of primate islet beta-cells. Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E91-E102
1	J:332289 Dobosz AM, Janikiewicz J, Krogulec E, Dziewulska A, Ajduk A, Szpila M, Nieznanska H, Szczepankiewicz AA, Wypych D, Dobrzyn A, Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of beta-cell identity and alpha-cell expansion in the mature pancreas. Mol Metab. 2022 Dec 15;67:101659
1	J:184887 Du A, McCracken KW, Walp ER, Terry NA, Klein TJ, Han A, Wells JM, May CL, Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol. 2012 May 1;365(1):175-88
1	J:141800 Edfalk S, Steneberg P, Edlund H, Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes. 2008 Sep;57(9):2280-7
1	J:89720 Fajas L, Annicotte JS, Miard S, Sarruf D, Watanabe M, Auwerx J, Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest. 2004 May;113(9):1288-95
1*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:129765 Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H, BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. Cell Metab. 2007 Mar;5(3):207-19
1	J:238301 Henley KD, Stanescu DE, Kropp PA, Wright CV, Won KJ, Stoffers DA, Gannon M, Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and beta-Cell Function. Cell Rep. 2016 Jun 21;15(12):2637-50
1	J:307816 Heymans C, Delcorte O, Spourquet C, Villacorte-Tabelin M, Dupasquier S, Achouri Y, Mahibullah S, Lemoine P, Balda MS, Matter K, Pierreux CE, Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function. Sci Rep. 2021 Jul 15;11(1):14519
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1	J:194010 Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, Pradevand S, McDonald A, Bonal C, Reimann F, Gribble F, Debril MB, Metzger D, Chambon P, Herrera P, Rutter GA, Prentki M, Thorens B, Wahli W, PPARbeta/delta affects pancreatic beta cell mass and insulin secretion in mice. J Clin Invest. 2012 Nov 1;122(11):4105-17
1	J:277787 Ikuta K, Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M, Kimura Y, Matsumoto Y, Kimura Y, Maruno T, Kanda K, Nishi K, Takaori K, Uemoto S, Takaishi S, Chiba T, Nishi E, Seno H, Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice. Gut. 2019 May;68(5):882-892
1*	J:127539 Joglekar MV, Parekh VS, Mehta S, Bhonde RR, Hardikar AA, MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3. Dev Biol. 2007 Nov 15;311(2):603-12
1	J:154990 Kang HS, Kim YS, ZeRuth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Foley J, Jetten AM, Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol. 2009 Dec;29(24):6366-79
1	J:241385 Kim SY, Lee JH, Merrins MJ, Gavrilova O, Bisteau X, Kaldis P, Satin LS, Rane SG, Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary beta-Cell Dysfunction to Progressive Depletion of beta-Cell Mass and Diabetes. J Biol Chem. 2017 Mar 03;292(9):3841-3853
1	J:306907 Kodani N, Nakae J, Kobayashi M, Kikuchi O, Kitamura T, Itoh H, FCoR-Foxo1 Axis Regulates alpha-Cell Mass through Repression of Arx Expression. iScience. 2020 Jan 24;23(1):100798
1	J:51571 Krapp A, Knofler M, Ledermann B, Burki K, Berney C, Zoerkler N, Hagenbuchle O, Wellauer PK, The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 1998 Dec 1;12(23):3752-63
1	J:94589 Lamotte L, Jackerott M, Bucchini D, Jami J, Joshi RL, Deltour L, Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain. Transgenic Res. 2004 Oct;13(5):463-73
1	J:164411 Lau J, Hebrok M, Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes. 2010 May;59(5):1211-21
1	J:211812 Lindahl M, Danilova T, Palm E, Lindholm P, Voikar V, Hakonen E, Ustinov J, Andressoo JO, Harvey BK, Otonkoski T, Rossi J, Saarma M, MANF is indispensable for the proliferation and survival of pancreatic beta cells. Cell Rep. 2014 Apr 24;7(2):366-75
1	J:346373 Liu B, Hua D, Shen L, Li T, Tao Z, Fu C, Tang Z, Yang J, Zhang L, Nie A, Jiang Y, Wang J, Li Y, Gu Y, Ning G, NPC1 is required for postnatal islet beta cell differentiation by maintaining mitochondria turnover. Theranostics. 2024;14(5):2058-2074
1	J:178173 Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L, Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 1;359(1):1-11
1	J:208967 Mazur MA, Winkler M, Ganic E, Colberg JK, Johansson JK, Bennet H, Fex M, Nuber UA, Artner I, Microphthalmia transcription factor regulates pancreatic beta-cell function. Diabetes. 2013 Aug;62(8):2834-42
1	J:200656 Mead TJ, Wang Q, Bhattaram P, Dy P, Afelik S, Jensen J, Lefebvre V, A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration. Nucleic Acids Res. 2013 Apr;41(8):4459-69
1	J:177060 Medina MC, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, Pileggi A, Hernandez A, Edlund H, Bianco AC, The Thyroid Hormone-Inactivating Type III Deiodinase Is Expressed in Mouse and Human {beta}-Cells and Its Targeted Inactivation Impairs Insulin Secretion. Endocrinology. 2011 Oct;152(10):3717-27
1	J:321229 Murakami-Kawaguchi S, Takasawa S, Onogawa T, Nata K, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Yamauchi A, Ota H, Takeda M, Kato M, Okamoto H, Expression of Ins1 and Ins2 genes in mouse fetal liver. Cell Tissue Res. 2014 Feb;355(2):303-14
1*	J:328290 Nakagawa T, Jorg DJ, Watanabe H, Mizuno S, Han S, Ikeda T, Omatsu Y, Nishimura K, Fujita M, Takahashi S, Kondoh G, Simons BD, Yoshida S, Nagasawa T, A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis. Cell Rep. 2021 Oct 19;37(3):109875
1	J:320679 Nlend RN, Ait-Lounis A, Allagnat F, Cigliola V, Charollais A, Reith W, Haefliger JA, Meda P, Cx36 is a target of Beta2/NeuroD1, which associates with prenatal differentiation of insulin-producing beta cells. J Membr Biol. 2012 Jun;245(5-6):263-73
1	J:312429 Noguchi H, Miyagi-Shiohira C, Kinjo T, Saitoh I, Watanabe M, In vivo evaluation of GG2-GG1/A2 element activity in the insulin promoter region using the CRISPR-Cas9 system. Sci Rep. 2021 Oct 13;11(1):20290
1	J:246400 Paul L, Walker EM, Drosos Y, Cyphert HA, Neale G, Stein R, South J, Grosveld G, Herrera PL, Sosa-Pineda B, Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine beta-Cells. Diabetes. 2016 Mar;65(3):687-98
1	J:306082 Quilichini E, Fabre M, Nord C, Dirami T, Le Marec A, Cereghini S, Pasek RC, Gannon M, Ahlgren U, Haumaitre C, Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease. J Pathol. 2021 May;254(1):31-45
1*	J:246476 Raum JC, Soleimanpour SA, Groff DN, Core N, Fasano L, Garratt AN, Dai C, Powers AC, Stoffers DA, Tshz1 Regulates Pancreatic beta-Cell Maturation. Diabetes. 2015 Aug;64(8):2905-14
1	J:208938 Reinert RB, Brissova M, Shostak A, Pan FC, Poffenberger G, Cai Q, Hundemer GL, Kantz J, Thompson CS, Dai C, McGuinness OP, Powers AC, Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes. 2013 Dec;62(12):4154-64
1	J:99302 Rosanas-Urgell A, Marfany G, Garcia-Fernandez J, Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets. Mol Cell Endocrinol. 2005 Jun 15;237(1-2):59-66
1	J:102106 Shroyer NF, Wallis D, Venken KJ, Bellen HJ, Zoghbi HY, Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 2005 Oct 15;19(20):2412-7
1	J:164654 Valtat B, Dupuis C, Zenaty D, Singh-Estivalet A, Tronche F, Breant B, Blondeau B, Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice. Diabetologia. 2011 Feb;54(2):350-9
1	J:129652 Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ, Teitelman G, Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation. Endocrinology. 2006 Sep;147(9):3995-4006
1	J:296911 Wang Y, Sun J, Lin Z, Zhang W, Wang S, Wang W, Wang Q, Ning G, m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine beta-Cells. Diabetes. 2020 Aug;69(8):1708-1722
1	J:280793 Wang Y, Sun J, Ni Q, Nie A, Gu Y, Wang S, Zhang W, Ning G, Wang W, Wang Q, Dual Effect of Raptor on Neonatal beta-Cell Proliferation and Identity Maintenance. Diabetes. 2019 Oct;68(10):1950-1964
1	J:132695 Wilding Crawford L, Tweedie Ables E, Oh YA, Boone B, Levy S, Gannon M, Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS One. 2008;3(2):e1611
1	J:174673 Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV, Context-specific {alpha}-to-{beta}-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011 Aug 15;25(16):1680-5
1	J:87724 Yoshitomi H, Zaret KS, Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development. 2004 Feb;131(4):807-17