Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Plp1  proteolipid protein (myelin) 1   (Synonyms: DM20, Plp)
Results	Reference
1	J:338878 Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L, Major beta cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504
1*	J:57684 Bongarzone ER, Campagnoni CW, Kampf K, Jacobs EC, Handley VW, Schonmann V, Campagnoni AT, Identification of a new exon in the myelin proteolipid protein gene encoding novel protein isoforms that are restricted to the somata of oligodendrocytes and neurons. J Neurosci. 1999 Oct 1;19(19):8349-57
1	J:154602 Chen Y, Wu H, Wang S, Koito H, Li J, Ye F, Hoang J, Escobar SS, Gow A, Arnett HA, Trapp BD, Karandikar NJ, Hsieh J, Lu QR, The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci. 2009 Nov;12(11):1398-406
1	J:148440 Corbeil D, Joester A, Fargeas CA, Jaszai J, Garwood J, Hellwig A, Werner HB, Huttner WB, Expression of distinct splice variants of the stem cell marker prominin-1 (CD133) in glial cells. Glia. 2009 Jun;57(8):860-74
1	J:58137 das Neves L, Duchala CS, Godinho F, Haxhiu MA, Colmenares C, Macklin WB, Campbell CE, Butz KG, Gronostajski RM, Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11946-51
1	J:37591 Dickinson PJ, Fanarraga ML, Griffiths IR, Barrie JM, Kyriakides E, Montague P, Oligodendrocyte progenitors in the embryonic spinal cord express DM-20. Neuropathol Appl Neurobiol. 1996 Jun;22(3):188-98
1	J:42690 Dickinson PJ, Griffiths IR, Barrie JM, Kyriakides E, Pollock GF, Barnett SC, Expression of the dm-20 isoform of the plp gene in olfactory nerve ensheathing cells: evidence from developmental studies. J Neurocytol. 1997 Mar;26(3):181-9
1	J:250520 Dubey M, Bugiani M, Ridder MC, Postma NL, Brouwers E, Polder E, Jacobs JG, Baayen JC, Klooster J, Kamermans M, Aardse R, de Kock CP, Dekker MP, van Weering JR, Heine VM, Abbink TE, Scheper GC, Boor I, Lodder JC, Mansvelder HD, van der Knaap MS, Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle. Ann Neurol. 2015 Jan;77(1):114-31
1	J:269212 Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ, Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294
1	J:38022 Fanarraga ML, Dickinson PJ, Sommer I, Montague P, Kyriakides E, Griffiths IR, Evidence that some oligodendrocyte progenitors in the developing optic pathway express the plp gene. Glia. 1996 Dec;18(4):282-92
1	J:316664 Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B, Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol. 2012 Aug;72(2):224-33
1	J:242754 Frohlich D, Suchowerska AK, Spencer ZH, von Jonquieres G, Klugmann CB, Bongers A, Delerue F, Stefen H, Ittner LM, Fath T, Housley GD, Klugmann M, In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL. Neurobiol Dis. 2017 Jan;97(Pt A):24-35
1	J:206315 Hoffmann SA, Hos D, Kuspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S, Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development. 2014 Jan;141(1):39-50
1*	J:85880 Jacobs EC, Bongarzone ER, Campagnoni CW, Kampf K, Campagnoni AT, Soma-restricted products of the myelin proteolipid gene are expressed primarily in neurons in the developing mouse nervous system. Dev Neurosci. 2003 Mar-Aug;25(2-4):96-104
1	J:81165 Kagawa T, Ikenaka K, Inoue Y, Kuriyama S, Tsujii T, Nakao J, Nakajima K, Aruga J, Okano H, Mikoshiba K, Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron. 1994 Aug;13(2):427-42
1	J:298091 Kao CS, van Bruggen R, Kim JR, Chen XXL, Chan C, Lee J, Cho WI, Zhao M, Arndt C, Maksimovic K, Khan M, Tan Q, Wilson MD, Park J, Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nat Commun. 2020 Oct 20;11(1):5304
1	J:309383 Kim J, Choi I, Lee Y, Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development. Histochem Cell Biol. 2017 Nov;148(5):489-501
1	J:159670 Kumar S, Biancotti JC, Matalon R, de Vellis J, Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease. J Neurosci Res. 2009 Nov 15;87(15):3415-27
1	J:294401 Lee H, Thacker S, Sarn N, Dutta R, Eng C, Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder. Transl Psychiatry. 2019 Jan 17;9(1):13
1	J:221126 Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B, Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18;85(6):1227-43
1	J:210605 Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH, Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 8;509(7499):189-94
1*	J:85925 Moreau-Fauvarque C, Kumanogoh A, Camand E, Jaillard C, Barbin G, Boquet I, Love C, Jones EY, Kikutani H, Lubetzki C, Dusart I, Chedotal A, The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. J Neurosci. 2003 Oct 8;23(27):9229-39
1*	J:129145 Nadon NL, Miller S, Draeger K, Salvaggio M, Myelin proteolipid DM20: evidence for function independent of myelination. Int J Dev Neurosci. 1997 Jun;15(3):285-93
1	J:305247 Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C, Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021 Apr;24(4):478-488
1	J:167272 Parenti R, Cicirata F, Zappala A, Catania A, La Delia F, Cicirata V, Tress O, Willecke K, Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia. 2010 Oct;58(13):1594-609
1	J:123227 See J, Mamontov P, Ahn K, Wine-Lee L, Crenshaw EB 3rd, Grinspan JB, BMP signaling mutant mice exhibit glial cell maturation defects. Mol Cell Neurosci. 2007 May;35(1):171-82
1	J:62287 Stecca B, Southwood CM, Gragerov A, Kelley KA, Friedrich VL Jr, Gow A, The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. J Neurosci. 2000 Jun 1;20(11):4002-10
1	J:192019 Touahri Y, Escalas N, Benazeraf B, Cochard P, Danesin C, Soula C, Sulfatase 1 promotes the motor neuron-to-oligodendrocyte fate switch by activating Shh signaling in Olig2 progenitors of the embryonic ventral spinal cord. J Neurosci. 2012 Dec 12;32(50):18018-34
1	J:229448 Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP, Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016 Jan 22;351(6271):379-84
1	J:317051 Tushaus J, Muller SA, Shrouder J, Arends M, Simons M, Plesnila N, Blobel CP, Lichtenthaler SF, The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system. FASEB J. 2021 Nov;35(11):e21962
1	J:310006 Weng Q, Wang J, Wang J, Tan B, Wang J, Wang H, Zheng T, Lu QR, Yang B, He Q, Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKalpha Activity. Sci Rep. 2017 May 11;7(1):1705