Assay
Age
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Immunohistochemistry (section)
Postnatal
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Pcsk2 proprotein convertase subtilisin/kexin type 2 (Synonyms: 6330411F23Rik, Nec2, Nec-2, PC2, Phpp-2, prohormone convertase 2, SPC2) | |
Results | Reference |
1 | J:188254 Budry L, Balsalobre A, Gauthier Y, Khetchoumian K, L'honore A, Vallette S, Brue T, Figarella-Branger D, Meij B, Drouin J, The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310 |
1* | J:191140 Grigoryan M, Kedees MH, Guz Y, Teitelman G, Phenotype of entero-endocrine L cells becomes restricted during development. Dev Dyn. 2012 Dec;241(12):1986-92 |
1 | J:96332 Lee CS, Sund NJ, Behr R, Herrera PL, Kaestner KH, Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol. 2005 Feb 15;278(2):484-95 |
1* | J:35634 Marcinkiewicz M, Day R, Seidah NG, Chretien M, Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4922-6 |
1 | J:20976 Marcinkiewicz M, Ramla D, Seidah NG, Chretien M, Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets. Endocrinology. 1994 Oct;135(4):1651-60 |
1 | J:183890 Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D, Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet. 2012 Apr;44(4):406-12, S1 |
1 | J:187963 Talchai C, Xuan S, Lin HV, Sussel L, Accili D, Pancreatic beta Cell Dedifferentiation as a Mechanism of Diabetic beta Cell Failure. Cell. 2012 Sep 14;150(6):1223-34 |
1 | J:85590 Vincent M, Guz Y, Rozenberg M, Webb G, Furuta M, Steiner D, Teitelman G, Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis. Endocrinology. 2003 Sep;144(9):4061-9 |
1 | J:129652 Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ, Teitelman G, Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation. Endocrinology. 2006 Sep;147(9):3995-4006 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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