Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lefty2  left-right determination factor 2   (Synonyms: 6030463A22Rik, Ebaf, Leftb)
Results	Reference
1	J:213344 Barratt KS, Glanville-Jones HC, Arkell RM, The Zic2 gene directs the formation and function of node cilia to control cardiac situs. Genesis. 2014 Jun;52(6):626-35
1	J:79098 Brennan J, Norris DP, Robertson EJ, Nodal activity in the node governs left-right asymmetry. Genes Dev. 2002 Sep 15;16(18):2339-44
1*	J:60975 Chang H, Zwijsen A, Vogel H, Huylebroeck D, Matzuk MM, Smad5 is essential for left-right asymmetry in mice. Dev Biol. 2000 Mar 1;219(1):71-8
1*	J:116645 Cota CD, Bagher P, Pelc P, Smith CO, Bodner CR, Gunn TM, Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis. Dev Dyn. 2006 Dec;235(12):3438-47
1*	J:178421 Dowdle WE, Robinson JF, Kneist A, Sirerol-Piquer MS, Frints SG, Corbit KC, Zaghloul NA, van Lijnschoten G, Mulders L, Verver DE, Zerres K, Reed RR, Attie-Bitach T, Johnson CA, Garcia-Verdugo JM, Katsanis N, Bergmann C, Reiter JF, Disruption of a ciliary B9 protein complex causes Meckel syndrome. Am J Hum Genet. 2011 Jul 15;89(1):94-110
1*	J:268103 Dykes IM, Szumska D, Kuncheria L, Puliyadi R, Chen CM, Papanayotou C, Lockstone H, Dubourg C, David V, Schneider JE, Keane TM, Adams DJ, Brown SDM, Mercier S, Odent S, Collignon J, Bhattacharya S, A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity. Sci Rep. 2018 Jul 11;8(1):10439
1	J:170490 Field S, Riley KL, Grimes DT, Hilton H, Simon M, Powles-Glover N, Siggers P, Bogani D, Greenfield A, Norris DP, Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2. Development. 2011 Mar;138(6):1131-42
1*	J:79391 Fujiwara T, Dehart DB, Sulik KK, Hogan BL, Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. Development. 2002 Oct;129(20):4685-96
1	J:140928 Furtado MB, Solloway MJ, Jones VJ, Costa MW, Biben C, Wolstein O, Preis JI, Sparrow DB, Saga Y, Dunwoodie SL, Robertson EJ, Tam PP, Harvey RP, BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev. 2008 Nov 1;22(21):3037-49
1	J:58530 Gaio U, Schweickert A, Fischer A, Garratt AN, Muller T, Ozcelik C, Lankes W, Strehle M, Britsch S, Blum M, Birchmeier C, A role of the cryptic gene in the correct establishment of the left-right axis. Curr Biol. 1999 Nov 18;9(22):1339-42
1*	J:119664 Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW, Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev Biol. 2006 Dec 15;300(2):523-33
1*	J:142123 Ishimura A, Chida S, Osada S, Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner. Dev Dyn. 2008 Dec;237(12):3565-76
1*	J:52218 King T, Beddington RS, Brown NA, The role of the brachyury gene in heart development and left-right specification in the mouse. Mech Dev. 1998 Dec;79(1-2):29-37
1	J:142430 Kumar A, Lualdi M, Lewandoski M, Kuehn MR, Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Dev Dyn. 2008 Dec;237(12):3591-601
1*	J:185804 Larkins CE, Long AB, Caspary T, Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia. Dev Biol. 2012 Jul 1;367(1):15-24
1*	J:93051 Marques S, Borges AC, Silva AC, Freitas S, Cordenonsi M, Belo JA, The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev. 2004 Oct 1;18(19):2342-7
1*	J:49270 Meno C, Ito Y, Saijoh Y, Matsuda Y, Tashiro K, Kuhara S, Hamada H, Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells. 1997 Aug;2(8):513-24
1	J:49052 Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S , Noji S , Kondoh H , Hamada H, lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell. 1998 Aug 7;94(3):287-97
1	J:70483 Meno C, Takeuchi J, Sakuma R, Koshiba-Takeuchi K, Ohishi S, Saijoh Y, Miyazaki J, ten Dijke P, Ogura T, Hamada H, Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev Cell. 2001 Jul;1(1):127-138
1	J:137629 Mine N, Anderson RM, Klingensmith J, BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. Development. 2008 Jul;135(14):2425-34
1	J:119568 Miura S, Davis S, Klingensmith J, Mishina Y, BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development. 2006 Oct;133(19):3767-75
1*	J:62025 Murcia NS, Richards WG, Yoder BK, Mucenski ML, Dunlap JR, Woychik RP, The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development. 2000 Jun;127(11):2347-55
1	J:111702 Murray SA, Gridley T, Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10300-4
1	J:104377 Nakaya MA, Biris K, Tsukiyama T, Jaime S, Rawls JA, Yamaguchi TP, Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation. Development. 2005 Dec;132(24):5425-36
1*	J:67816 Niederreither K, Vermot J, Messaddeq N, Schuhbaur B, Chambon P, Dolle P, Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development. 2001 Apr;128(7):1019-31
1	J:51419 Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N, Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell. 1998 Dec 11;95(6):829-37
1	J:126337 Oki S, Hashimoto R, Okui Y, Shen MM, Mekada E, Otani H, Saijoh Y, Hamada H, Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development. 2007 Nov;134(21):3893-904
1	J:154981 Oki S, Kitajima K, Marques S, Belo JA, Yokoyama T, Hamada H, Meno C, Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos. Development. 2009 Dec;136(23):3917-25
1*	J:77401 Pennekamp P, Karcher C, Fischer A, Schweickert A, Skryabin B, Horst J, Blum M, Dworniczak B, The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol. 2002 Jun 4;12(11):938-43
1	J:60755 Rankin CT, Bunton T, Lawler AM, Lee SJ, Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat Genet. 2000 Mar;24(3):262-5
1*	J:60152 Saijoh Y, Adachi H, Sakuma R, Yeo CY, Yashiro K, Watanabe M, Hashiguchi H, Mochida K, Ohishi S, Kawabata M, Miyazono K, Whitman M, Hamada H, Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol Cell. 2000 Jan;5(1):35-47
1	J:82703 Saijoh Y, Oki S, Ohishi S, Hamada H, Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003 Apr 1;256(1):160-72
1	J:278278 Sasaki K, Shiba K, Nakamura A, Kawano N, Satouh Y, Yamaguchi H, Morikawa M, Shibata D, Yanase R, Jokura K, Nomura M, Miyado M, Takada S, Ueno H, Nonaka S, Baba T, Ikawa M, Kikkawa M, Miyado K, Inaba K, Calaxin is required for cilia-driven determination of vertebrate laterality. Commun Biol. 2019;2:226
1	J:185535 Saund RS, Kanai-Azuma M, Kanai Y, Kim I, Lucero MT, Saijoh Y, Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. Development. 2012 Jul;139(13):2426-35
1*	J:253966 Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G 3rd, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF, Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 Dec 18;43(6):744-762.e11
1	J:162640 Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y, Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature. 2010 Jul 15;466(7304):378-82
1	J:245906 Sugrue KF, Zohn IE, Mechanism for generation of left isomerism in Ccdc40 mutant embryos. PLoS One. 2017;12(2):e0171180
1*	J:252050 Sung YH, Baek IJ, Kim YH, Gho YS, Oh SP, Lee YJ, Lee HW, PIERCE1 is critical for specification of left-right asymmetry in mice. Sci Rep. 2016 Jun 16;6:27932
1	J:155112 Tsiairis CD, McMahon AP, An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Curr Biol. 2009 Dec 1;19(22):1912-7
1*	J:57950 Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magallon J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC, Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11376-81
1	J:122745 Vierkotten J, Dildrop R, Peters T, Wang B, Ruther U, Ftm is a novel basal body protein of cilia involved in Shh signalling. Development. 2007 Jul;134(14):2569-77
1*	J:58413 Wasiak S, Lohnes D, Retinoic acid affects left-right patterning. Dev Biol. 1999 Nov 15;215(2):332-42
1*	J:64329 Welsh IC, O'Brien TP, Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse. Dev Biol. 2000 Sep 1;225(1):151-68
1*	J:82311 Yamamoto M, Mine N, Mochida K, Sakai Y, Saijoh Y, Meno C, Hamada H, Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development. 2003 May;130(9):1795-804
1	J:58104 Yan YT, Gritsman K, Ding J, Burdine RD, Corrales JD, Price SM, Talbot WS, Schier AF, Shen MM, Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev. 1999 Oct 1;13(19):2527-37
1*	J:113766 Zhang M, Bolfing MF, Knowles HJ, Karnes H, Hackett BP, Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice. Biochem Biophys Res Commun. 2004 Nov 26;324(4):1413-20
1	J:175111 Zhang XM, Ramalho-Santos M, McMahon AP, Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell. 2001 Jul 27;106(2):781-92