Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Spp1  secreted phosphoprotein 1   (Synonyms: 2ar, 44kDa bone phosphoprotein, Apl-1, BNSP, bone sialoprotein 1, ETA-1, minopontin, OP, Opn, Opnl, osteopontin, osteopontin-like protein, Ric, Spp-1)
Results	Reference
1	J:181527 Chaible LM, Sanches DS, Cogliati B, Mennecier G, Dagli ML, Delayed osteoblastic differentiation and bone development in Cx43 knockout mice. Toxicol Pathol. 2011 Dec;39(7):1046-55
1	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1	J:188305 Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y, Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol. 2012 May;31(4):234-45
1	J:233766 Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, Ito K, Izumi S, Komori T, Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. J Bone Miner Res. 2016 Jul;31(7):1391-404
1*	J:203695 Lieben L, Stockmans I, Moermans K, Carmeliet G, Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. Bone. 2013 Nov;57(1):123-31
1	J:333798 Luo S, Liu Z, Bian Q, Wang X, Ectomesenchymal Six1 controls mandibular skeleton formation. Front Genet. 2023;14:1082911
1	J:320175 Maeda Y, Miwa Y, Sato I, Expression of CGRP, vasculogenesis and osteogenesis associated mRNAs in the developing mouse mandible and tibia. Eur J Histochem. 2017 Jan 23;61(1):2750
1*	J:74493 Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, Bouillon R, Carmeliet G, Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF(164) and VEGF(188). Mech Dev. 2002 Feb;111(1-2):61-73
1	J:176132 O'Leary J, Osborne LR, Global analysis of gene expression in the developing brain of gtf2ird1 knockout mice. PLoS One. 2011;6(8):e23868
1*	J:178075 Peacock JD, Huk DJ, Ediriweera HN, Lincoln J, Sox9 transcriptionally represses spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS One. 2011;6(10):e26769
1	J:224392 Poncy A, Antoniou A, Cordi S, Pierreux CE, Jacquemin P, Lemaigre FP, Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev Biol. 2015 Aug 15;404(2):136-48
1	J:320731 Sandovici I, Georgopoulou A, Perez-Garcia V, Hufnagel A, Lopez-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constancia M, The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Dev Cell. 2022 Jan 10;57(1):63-79.e8
1	J:326699 Tosun B, Wolff LI, Houben A, Nutt S, Hartmann C, Osteoclasts and Macrophages-Their Role in Bone Marrow Cavity Formation During Mouse Embryonic Development. J Bone Miner Res. 2022 Jun 11;
1	J:341147 Young RE, Jones MK, Hines EA, Li R, Luo Y, Shi W, Verheyden JM, Sun X, Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching. Dev Cell. 2020 Apr 6;53(1):73-85.e5