Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Amy  amylase complex
Results	Reference
1	J:219809 Afelik S, Pool B, Schmerr M, Penton C, Jensen J, Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development. Dev Biol. 2015 Mar 15;399(2):204-17
1	J:184016 Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J, Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells. Development. 2012 May;139(10):1744-53
1	J:305792 Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U, Lickert H, Inceptor counteracts insulin signalling in beta-cells to control glycaemia. Nature. 2021 Feb;590(7845):326-331
1	J:187468 Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L, Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis. 2012 Aug;50(8):612-24
1	J:240765 Arregi I, Climent M, Iliev D, Strasser J, Gouignard N, Johansson JK, Singh T, Mazur M, Semb H, Artner I, Minichiello L, Pera EM, Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling. Endocrinology. 2016 Dec;157(12):4615-4631
1	J:111685 Asayesh A, Sharpe J, Watson RP, Hecksher-Sorensen J, Hastie ND, Hill RE, Ahlgren U, Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice. Genes Dev. 2006 Aug 15;20(16):2208-13
1	J:204532 Balderes DA, Magnuson MA, Sussel L, Nkx2.2:Cre knock-in mouse line: A novel tool for pancreas- and CNS-specific gene deletion. Genesis. 2013 Dec;51(12):844-51
1	J:284608 Campbell SA, McDonald CL, Krentz NAJ, Lynn FC, Hoffman BG, TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation. Cell Rep. 2019 Aug 13;28(7):1830-1844.e6
1	J:239144 Direnzo D, Hess DA, Damsz B, Hallett JE, Marshall B, Goswami C, Liu Y, Deering T, Macdonald RJ, Konieczny SF, Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells. Gastroenterology. 2012 Aug;143(2):469-80
1	J:119914 Doyle MJ, Loomis ZL, Sussel L, Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development. 2007 Feb;134(3):515-23
1	J:198451 El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G, Smad signaling pathways regulate pancreatic endocrine development. Dev Biol. 2013 Jun 15;378(2):83-93
1	J:267596 Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli FM, Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nat Commun. 2018 Nov 30;9(1):5082
1	J:129665 Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K, Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab. 2006 Jan;3(1):59-65
1	J:168727 Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa S, Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, Uemoto S, Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2011 Jan;43(1):34-41
1	J:112173 Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C, The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev. 2006 Sep 1;20(17):2465-78
1*	J:84902 Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J, Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol. 2003 Aug 15;260(2):426-37
1	J:214089 Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ, The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
1	J:65293 Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA, Regulation of pancreas development by hedgehog signaling. Development. 2000 Nov;127(22):4905-13
1	J:254462 Hibsher D, Epshtein A, Oren N, Landsman L, Pancreatic Mesenchyme Regulates Islet Cellular Composition in a Patched/Hedgehog-Dependent Manner. Sci Rep. 2016 Nov 28;6:38008
1	J:184814 Horn S, Kobberup S, Jorgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Ronne J, Jensen JN, Mind bomb 1 is required for pancreatic beta-cell formation. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61
1	J:208600 Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL, Islet alpha-, beta-, and delta-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes. 2013 Mar;62(3):875-86
1	J:163480 Johansson JK, Voss U, Kesavan G, Kostetskii I, Wierup N, Radice GL, Semb H, N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis. 2010 Jun;48(6):374-81
1	J:166952 Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS, Dachshund homologues play a conserved role in islet cell development. Dev Biol. 2010 Dec 15;348(2):143-52
1*	J:85472 Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M, Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development. 2003 Oct;130(20):4871-9
1	J:236027 Khoriaty R, Everett L, Chase J, Zhu G, Hoenerhoff M, McKnight B, Vasievich MP, Zhang B, Tomberg K, Williams J, Maillard I, Ginsburg D, Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice. Sci Rep. 2016 Jun 14;6:27802
1*	J:79280 Kido Y, Nakae J, Hribal ML, Xuan S, Efstratiadis A, Accili D, Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and beta -Cell Compensation to Insulin Resistance. J Biol Chem. 2002 Sep 27;277(39):36740-7
1	J:125767 Kobberup S, Nyeng P, Juhl K, Hutton J, Jensen J, ETS-family genes in pancreatic development. Dev Dyn. 2007 Nov;236(11):3100-10
1	J:170126 Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M, Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011 Feb;138(4):653-65
1	J:294656 Kropp PA, Zhu X, Gannon M, Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6. Cell Mol Gastroenterol Hepatol. 2019;7(4):841-856
1*	J:182781 Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M, Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011 Sep;9(9):e1001143
1	J:239872 Larsen BM, Hrycaj SM, Newman M, Li Y, Wellik DM, Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation. Development. 2015 Nov 15;142(22):3859-68
1*	J:132315 Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS, MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes. 2007 Dec;56(12):2938-45
1	J:225823 Martin D, Kim YH, Sever D, Mao CA, Haefliger JA, Grapin-Botton A, REST represses a subset of the pancreatic endocrine differentiation program. Dev Biol. 2015 Sep 15;405(2):316-27
1	J:334331 Melzer MK, Schirge S, Gout J, Arnold F, Srinivasan D, Burtscher I, Allgower C, Mulaw M, Zengerling F, Gunes C, Lickert H, Christoffels VM, Liebau S, Wagner M, Seufferlein T, Bolenz C, Moon AM, Perkhofer L, Kleger A, TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration. BMC Biol. 2023 Mar 20;21(1):55
1	J:254493 Munoz-Bravo JL, Flores-Martinez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA, Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity. PLoS One. 2016;11(10):e0164714
1	J:139250 Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, Algul H, Radtke F, Strobl L, Zimber-Strobl U, Schmid RM, Conditional ablation of Notch signaling in pancreatic development. Development. 2008 Aug;135(16):2757-65
1	J:138933 Nakhai H, Siveke JT, Mendoza-Torres L, Schmid RM, Conditional inactivation of Myc impairs development of the exocrine pancreas. Development. 2008 Oct;135(19):3191-6
1*	J:86842 Norgaard GA, Jensen JN, Jensen J, FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol. 2003 Dec 15;264(2):323-38
1	J:284168 Nyeng P, Heilmann S, Lof-Ohlin ZM, Pettersson NF, Hermann FM, Reynolds AB, Semb H, p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate. Dev Cell. 2019 Apr 8;49(1):31-47.e9
1	J:306470 Osipovich AB, Dudek KD, Greenfest-Allen E, Cartailler JP, Manduchi E, Potter Case L, Choi E, Chapman AG, Clayton HW, Gu G, Stoeckert CJ Jr, Magnuson MA, A developmental lineage-based gene co-expression network for mouse pancreatic beta-cells reveals a role for Zfp800 in pancreas development. Development. 2021 Mar 21;148(6):dev196964
1*	J:309372 Padgett LR, Robertson MA, Anderson-Baucum EK, Connors CT, Wu W, Mirmira RG, Mastracci TL, Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development. FASEB J. 2021 May;35(5):e21473
1	J:187872 Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA, A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Genesis. 2012 Apr;50(4):384-92
1*	J:82083 Pulkkinen MA, Spencer-Dene B, Dickson C, Otonkoski T, The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells. Mech Dev. 2003 Feb;120(2):167-75
1*	J:333559 Rupani DN, Thege FI, Chandra V, Rajaei H, Cowan RW, Wormann SM, Le Roux O, Malaney P, Manning SL, Hashem J, Bailey-Lundberg J, Rhim AD, McAllister F, Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling. Development. 2023 Jan 15;150(2):dev201097
1	J:297252 Seymour PA, Collin CA, Egeskov-Madsen AR, Jorgensen MC, Shimojo H, Imayoshi I, de Lichtenberg KH, Kopan R, Kageyama R, Serup P, Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Dev Cell. 2020 Mar 23;52(6):731-747.e8
1	J:141017 Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M, A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008 Nov 1;323(1):19-30
1	J:119758 Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, Scherer G, Sander M, SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1865-70
1*	J:29896 Sjodin A, Dahl U, Semb H, Mouse R-cadherin: expression during the organogenesis of pancreas and gastrointestinal tract. Exp Cell Res. 1995 Dec;221(2):413-25
1	J:48576 Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA , Rubenstein JL , German MS, Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun;125(12):2213-21
1	J:186391 Tao J, Zhu M, Wang H, Afelik S, Vasievich MP, Chen XW, Zhu G, Jensen J, Ginsburg D, Zhang B, SEC23B is required for the maintenance of murine professional secretory tissues. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):E2001-9
1	J:121629 Tulachan SS, Tei E, Hembree M, Crisera C, Prasadan K, Koizumi M, Shah S, Guo P, Bottinger E, Gittes GK, TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Dev Biol. 2007 May 15;305(2):508-521
1	J:156550 Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma A, OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia. 2010 Jan;53(1):115-22