Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lef1  lymphoid enhancer binding factor 1   (Synonyms: Lef-1, lymphoid enhancer factor 1)
Results	Reference
1	J:314666 Balasubramanian R, Min X, Quinn PMJ, Giudice QL, Tao C, Polanco K, Makrides N, Peregrin J, Bouaziz M, Mao Y, Wang Q, da Costa BL, Buenaventura D, Wang F, Ma L, Tsang SH, Fabre PJ, Zhang X, Phase transition specified by a binary code patterns the vertebrate eye cup. Sci Adv. 2021 Nov 12;7(46):eabj9846
1*	J:228706 Chandramouli A, Simundza J, Pinderhughes A, Hiremath M, Droguett G, Frendewey D, Cowin P, Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution. Breast Cancer Res. 2013;15(6):R111
1	J:183485 Chen D, Jarrell A, Guo C, Lang R, Atit R, Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development. 2012 Apr;139(8):1522-33
1*	J:248190 Chen K, Quan H, Chen G, Xiao D, Spatio-temporal expression patterns of Wnt signaling pathway during the development of temporomandibular condylar cartilage. Gene Expr Patterns. 2017 Nov;25-26:149-158
1	J:196652 Choe Y, Kozlova A, Graf D, Pleasure SJ, Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci. 2013 Apr 17;33(16):6766-75
1	J:182705 Choe Y, Siegenthaler JA, Pleasure SJ, A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron. 2012 Feb 23;73(4):698-712
1	J:205544 Dai D, Li L, Huebner A, Zeng H, Guevara E, Claypool DJ, Liu A, Chen J, Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ. 2013 Jan;20(1):130-8
1	J:207219 Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM, Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature. 2013 Dec 12;504(7479):277-81
1	J:304642 Dupacova N, Antosova B, Paces J, Kozmik Z, Meis homeobox genes control progenitor competence in the retina. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2013136118
1	J:308456 Eliason S, Sharp T, Sweat M, Sweat YY, Amendt BA, Ectodermal Organ Development Is Regulated by a microRNA-26b-Lef-1-Wnt Signaling Axis. Front Physiol. 2020;11:780
1	J:213513 Gao Y, Toska E, Denmon D, Roberts SG, Medler KF, WT1 regulates the development of the posterior taste field. Development. 2014 Jun;141(11):2271-8
1	J:189063 Goodnough LH, Chang AT, Treloar C, Yang J, Scacheri PC, Atit RP, Twist1 mediates repression of chondrogenesis by beta-catenin to promote cranial bone progenitor specification. Development. 2012 Dec;139(23):4428-38
1	J:272582 Gupta K, Levinsohn J, Linderman G, Chen D, Sun TY, Dong D, Taketo MM, Bosenberg M, Kluger Y, Choate K, Myung P, Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis. Dev Cell. 2019 Jan 7;48(1):17-31.e6
1	J:197815 Hashimoto S, Chen H, Que J, Brockway BL, Drake JA, Snyder JC, Randell SH, Stripp BR, beta-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. J Cell Sci. 2012 Feb 15;125(Pt 4):932-42
1	J:300508 Hilliard SA, Li Y, Dixon A, El-Dahr SS, Mdm4 controls ureteric bud branching via regulation of p53 activity. Mech Dev. 2020 Sep;163:103616
1*	J:207609 Hilliard SA, Yao X, El-Dahr SS, Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014 Mar 1;387(1):1-14
1	J:193958 Huh SH, Narhi K, Lindfors PH, Haara O, Yang L, Ornitz DM, Mikkola ML, Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013 Feb 15;27(4):450-8
1	J:239871 Jussila M, Aalto AJ, Sanz Navarro M, Shirokova V, Balic A, Kallonen A, Ohyama T, Groves AK, Mikkola ML, Thesleff I, Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning. Development. 2015 Nov 15;142(22):3954-63
1	J:308827 Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V, MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development. 2021 May 15;148(10):dev192054
1	J:171430 Kobayashi A, Stewart CA, Wang Y, Fujioka K, Thomas NC, Jamin SP, Behringer RR, {beta}-Catenin is essential for Mullerian duct regression during male sexual differentiation. Development. 2011 May;138(10):1967-75
1	J:227517 Koizumi M, Oyama K, Yamakami Y, Kida T, Satoh R, Kato S, Hidema S, Oe T, Goto T, Clevers H, Nawa A, Nishimori K, Lgr4 controls specialization of female gonads in mice. Biol Reprod. 2015 Oct;93(4):90
1	J:309667 Kousa YA, Fuller E, Schutte BC, IRF6 and AP2A Interaction Regulates Epidermal Development. J Invest Dermatol. 2018 Dec;138(12):2578-2588
1*	J:308476 Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo BK, Clevers H, Greenfield A, Schedl A, Chaboissier MC, Chassot AA, Arrest of WNT/beta-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2023376118
1	J:168590 LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE, Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell. 2010 Dec 14;19(6):807-18
1	J:306027 Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, Matlik K, Olfat S, Montano-Rodriguez AR, Huh SH, Costantini F, Andressoo JO, Kuure S, Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development. 2021 May 15;148(10):dev197475
1	J:175262 Lin C, Fisher AV, Yin Y, Maruyama T, Veith GM, Dhandha M, Huang GJ, Hsu W, Ma L, The inductive role of Wnt-beta-Catenin signaling in the formation of oral apparatus. Dev Biol. 2011 Aug 1;356(1):40-50
1	J:221095 Liu B, Chen S, Cheng D, Jing W, Helms JA, Primary cilia integrate hedgehog and Wnt signaling during tooth development. J Dent Res. 2014 May;93(5):475-82
1*	J:263032 Magella B, Mahoney R, Adam M, Potter SS, Reduced Abd-B Hox function during kidney development results in lineage infidelity. Dev Biol. 2018 Jun 15;438(2):84-93
1*	J:194034 Mazahery AR, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Orvis GD, Behringer RR, Yamada G, Functional analysis of ectodermal beta-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013 Mar;53(1):34-41
1*	J:50471 McGowan KM, Coulombe PA, Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. J Cell Biol. 1998 Oct 19;143(2):469-86
1*	J:86666 Michno K, Boras-Granic K, Mill P, Hui CC, Hamel PA, Shh expression is required for embryonic hair follicle but not mammary gland development. Dev Biol. 2003 Dec 1;264(1):153-65
1	J:173242 Moisan A, Rivera MN, Lotinun S, Akhavanfard S, Coffman EJ, Cook EB, Stoykova S, Mukherjee S, Schoonmaker JA, Burger A, Kim WJ, Kronenberg HM, Baron R, Haber DA, Bardeesy N, The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification. Dev Cell. 2011 May 17;20(5):583-96
1	J:91317 Okubo T, Hogan BL, Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. J Biol. 2004;3(3):11
1	J:234114 Petit FG, Deng C, Jamin SP, Partial Mullerian Duct Retention in Smad4 Conditional Mutant Male Mice. Int J Biol Sci. 2016;12(6):667-76
1	J:298694 Rattner A, Terrillion CE, Jou C, Kleven T, Hu SF, Williams J, Hou Z, Aggarwal M, Mori S, Shin G, Goff LA, Witter MP, Pletnikov M, Fenton AA, Nathans J, Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. Elife. 2020 Oct 21;9:e62766
1	J:244798 Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R, Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons. J Am Soc Nephrol. 2015 May;26(5):1081-91
1	J:195266 Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H, Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
1	J:149989 Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA, KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development. 2009 Jul;136(13):2153-64
1	J:257052 Roker LA, Nemri K, Yu J, Wnt7b Signaling from the Ureteric Bud Epithelium Regulates Medullary Capillary Development. J Am Soc Nephrol. 2017 Jan;28(1):250-259
1	J:237499 Sima J, Piao Y, Chen Y, Schlessinger D, Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development. Development. 2016 Dec 15;143(24):4723-4735
1	J:228872 Song R, Preston G, Kidd L, Bushnell D, Sims-Lucas S, Bates CM, Yosypiv IV, Prorenin receptor is critical for nephron progenitors. Dev Biol. 2016 Jan 15;409(2):382-91
1	J:342842 Su D, Eliason S, Sun Z, Shao F, Amendt BA, Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development. J Biol Chem. 2023 Nov;299(11):105324
1*	J:73304 Tebar M, Destree O, de Vree WJ, Ten Have-Opbroek AA, Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung. Mech Dev. 2001 Dec;109(2):437-40
1*	J:18378 van Genderen C, Okamura RM, Farinas I, Quo RG, Parslow TG, Bruhn L, Grosschedl R, Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 1994 Nov 15;8(22):2691-703
1	J:290543 Vidal VP, Jian-Motamedi F, Rekima S, Gregoire EP, Szenker-Ravi E, Leushacke M, Reversade B, Chaboissier MC, Schedl A, R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors. Elife. 2020 May 1;9:e53895
1	J:330616 Wang F, Ngo J, Li Y, Liu H, Chen CH, Saifudeen Z, Sequeira-Lopez MLS, El-Dahr SS, Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia. Epigenetics. 2021 Nov;16(11):1235-1250
1	J:306208 Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X, FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biol. 2020 Jul 14;18(1):87
1	J:245600 Xie Y, Kaufmann D, Moulton MJ, Panahi S, Gaynes JA, Watters HN, Zhou D, Xue HH, Fung CM, Levine EM, Letsou A, Brennan KC, Dorsky RI, Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biol. 2017 Aug;15(8):e2002257
1	J:195126 Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM 3rd, Reichardt LF, Marciano DK, De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity. Development. 2013 Apr;140(8):1774-84
1	J:264522 Youngblood JL, Coleman TF, Davis SW, Regulation of Pituitary Progenitor Differentiation by beta-Catenin. Endocrinology. 2018 Sep 1;159(9):3287-3305
1	J:177881 Zhang Z, Wlodarczyk BJ, Niederreither K, Venugopalan S, Florez S, Finnell RH, Amendt BA, Fuz regulates craniofacial development through tissue specific responses to signaling factors. PLoS One. 2011;6(9):e24608