Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sox9  SRY (sex determining region Y)-box 9   (Synonyms: 2010306G03Rik)
Results	Reference
1	J:250302 Bagheri-Fam S, Bird AD, Zhao L, Ryan JM, Yong M, Wilhelm D, Koopman P, Eswarakumar VP, Harley VR, Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2. Endocrinology. 2017 Nov 01;158(11):3832-3843
1	J:226487 Bagheri-Fam S, Ono M, Li L, Zhao L, Ryan J, Lai R, Katsura Y, Rossello FJ, Koopman P, Scherer G, Bartsch O, Eswarakumar JV, Harley VR, FGFR2 mutation in 46,XY sex reversal with craniosynostosis. Hum Mol Genet. 2015 Dec 1;24(23):6699-710
1*	J:150223 Beverdam A, Svingen T, Bagheri-Fam S, Bernard P, McClive P, Robson M, Khojasteh MB, Salehi M, Sinclair AH, Harley VR, Koopman P, Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice. Reproduction. 2009 Mar;137(3):481-6
1*	J:164222 Beverdam A, Svingen T, Bagheri-Fam S, McClive P, Sinclair AH, Harley VR, Koopman P, Protein tyrosine kinase 2 beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads. Dev Dyn. 2010 Oct;239(10):2735-41
1*	J:93500 Bouma GJ, Hart GT, Washburn LL, Recknagel AK, Eicher EM, Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Gene Expr Patterns. 2004 Nov;5(1):141-9
1*	J:271281 Bowles J, Feng CW, Ineson J, Miles K, Spiller CM, Harley VR, Sinclair AH, Koopman P, Retinoic Acid Antagonizes Testis Development in Mice. Cell Rep. 2018 Jul 31;24(5):1330-1341
1	J:149785 Bradford ST, Hiramatsu R, Maddugoda MP, Bernard P, Chaboissier MC, Sinclair A, Schedl A, Harley V, Kanai Y, Koopman P, Wilhelm D, The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice. Biol Reprod. 2009 Jun;80(6):1178-88
1	J:279716 Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, Carroll TJ, Stanger BZ, Cleaver O, LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
1	J:226411 Caprioli A, Villasenor A, Wylie LA, Braitsch C, Marty-Santos L, Barry D, Karner CM, Fu S, Meadows SM, Carroll TJ, Cleaver O, Wnt4 is essential to normal mammalian lung development. Dev Biol. 2015 Oct 15;406(2):222-34
1	J:185786 Chawengsaksophak K, Svingen T, Ng ET, Epp T, Spiller CM, Clark C, Cooper H, Koopman P, Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biol Reprod. 2012 Jan;86(1):1-12
1	J:223357 Chen Q, Zhang L, de Crombrugghe B, Krahe R, Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation. FASEB J. 2015 Jun;29(6):2555-65
1	J:282642 Despang A, Schopflin R, Franke M, Ali S, Jerkovic I, Paliou C, Chan WL, Timmermann B, Wittler L, Vingron M, Mundlos S, Ibrahim DM, Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture. Nat Genet. 2019 Aug;51(8):1263-1271
1*	J:192988 DiTacchio L, Bowles J, Shin S, Lim DS, Koopman P, Janknecht R, Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J Biol Chem. 2012 Jul 6;287(28):23657-66
1	J:290670 Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ, Mainpal R, Totonchi M, Mohseni Meybodi A, Askari M, Merel-Chali T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Perez Garrido N, Berensztein E, Mekkawy MK, Schimenti JC, Bertalan R, Mazen I, McElreavey K, Belgorosky A, Lovell-Badge R, Rajkovic A, Bashamboo A, Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13680-13688
1*	J:314338 Gajjala PR, Kasam RK, Soundararajan D, Sinner D, Huang SK, Jegga AG, Madala SK, Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis. JCI Insight. 2021 Oct 22;6(20):e152503
1	J:152858 Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D, Ottolenghi C, Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol. 2009;9:36
1	J:263354 Gonen N, Futtner CR, Wood S, Garcia-Moreno SA, Salamone IM, Samson SC, Sekido R, Poulat F, Maatouk DM, Lovell-Badge R, Sex reversal following deletion of a single distal enhancer of Sox9. Science. 2018 Jun 29;360(6396):1469-1473
1*	J:238708 Gonen N, Quinn A, O'Neill HC, Koopman P, Lovell-Badge R, Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet. 2017 Jan;13(1):e1006520
1	J:338900 Huang R, Zhang C, Zheng Y, Zhang W, Huang H, Qiu M, Li J, Li F, ISL1 regulates lung branching morphogenesis via Shh signaling pathway. J Biol Chem. 2023 Jul 11;299(8):105034
1	J:303384 Ikeda Y, Tagami A, Maekawa M, Nagai A, The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation. Sci Rep. 2021 Feb 24;11(1):4486
1	J:178424 Kashimada K, Svingen T, Feng CW, Pelosi E, Bagheri-Fam S, Harley VR, Schlessinger D, Bowles J, Koopman P, Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J. 2011 Oct;25(10):3561-9
1*	J:35808 Kent J, Wheatley SC, Andrews JE, Sinclair AH, Koopman P, A male-specific role for SOX9 in vertebrate sex determination. Development. 1996 Sep;122(9):2813-22
1	J:198327 Kim EJ, Cho SW, Shin JO, Lee MJ, Kim KS, Jung HS, Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model. PLoS One. 2013;8(2):e55296
1	J:316198 Lei R, Zhang K, Liu K, Shao X, Ding Z, Wang F, Hong Y, Zhu M, Li H, Li H, Transferrin receptor facilitates TGF-beta and BMP signaling activation to control craniofacial morphogenesis. Cell Death Dis. 2016 Jun 30;7(6):e2282
1	J:214809 Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, Dubois E, Nidelet S, Nakamura M, Urade Y, Poulat F, Boizet-Bonhoure B, Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71
1*	J:293110 Moreno-Mendoza N, Torres-Maldonado L, Chimal-Monroy J, Harley V, Merchant-Larios H, Disturbed expression of Sox9 in pre-sertoli cells underlies sex-reversal in mice b6.Ytir. Biol Reprod. 2004 Jan;70(1):114-22
1	J:254493 Munoz-Bravo JL, Flores-Martinez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA, Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity. PLoS One. 2016;11(10):e0164714
1	J:216376 Nagahama Y, Sone M, Chen X, Okada Y, Yamamoto M, Xin B, Matsuo Y, Komatsu M, Suzuki A, Enomoto K, Nishikawa Y, Contributions of hepatocytes and bile ductular cells in ductular reactions and remodeling of the biliary system after chronic liver injury. Am J Pathol. 2014;184(11):3001-12
1	J:334329 Ogawa Y, Terao M, Tsuji-Hosokawa A, Tsuchiya I, Hasegawa M, Takada S, SOX9 and SRY binding sites on mouse mXYSRa/Enh13 enhancer redundantly regulate Sox9 expression to varying degrees. Hum Mol Genet. 2023 Jan 1;32(1):55-64
1	J:342643 Oh Y, Kasu M, Bottoms CJ, Douglas JC, Sekulovski N, Hayashi K, MacLean Ii JA, Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice. Biol Reprod. 2023 Oct 13;109(4):520-532
1	J:152582 Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA, The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest. 2009 Jul;119(7):1888-98
1	J:222045 Padua MB, Jiang T, Morse DA, Fox SC, Hatch HM, Tevosian SG, Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
1	J:172637 Park S, Zeidan K, Shin JS, Taketo T, SRY upregulation of SOX9 is inefficient and delayed, allowing ovarian differentiation, in the B6.Y(TIR) gonad. Differentiation. 2011 Jul;82(1):18-27
1	J:145808 Park SY, Lee EJ, Emge D, Jahn CL, Jameson JL, A phenotypic spectrum of sexual development in Dax1 (Nr0b1)-deficient mice: consequence of the C57BL/6J strain on sex determination. Biol Reprod. 2008 Dec;79(6):1038-45
1*	J:222912 Parma P, Radi O, Vidal V, Chaboissier MC, Dellambra E, Valentini S, Guerra L, Schedl A, Camerino G, R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet. 2006 Nov;38(11):1304-9
1*	J:186533 Pennekamp P, Feldner S, Seesing FJ, Psathaki OE, Scholer HR, Wieacker P, Dworniczak B, Bcar3 is expressed in sertoli cells and germ cells of the developing testis in mice. Sex Dev. 2011;5(4):197-204
1*	J:156949 Perez WD, Weller CR, Shou S, Stadler HS, Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development. Dev Dyn. 2010 Feb;239(2):446-57
1	J:155544 Polanco JC, Wilhelm D, Davidson TL, Knight D, Koopman P, Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development. Hum Mol Genet. 2010 Feb 1;19(3):506-16
1*	J:142977 Polanco JC, Wilhelm D, Mizusaki H, Jackson A, Browne C, Davidson T, Harley V, Sinclair A, Koopman P, Functional analysis of the SRY-KRAB interaction in mouse sex determination. Biol Cell. 2009 Jan;101(1):55-67
1*	J:122569 Puri S, Hebrok M, Dynamics of embryonic pancreas development using real-time imaging. Dev Biol. 2007 Jun 1;306(1):82-93
1	J:245904 Rudigier LJ, Dame C, Scholz H, Kirschner KM, Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation. PLoS One. 2017;12(4):e0176296
1*	J:209131 Saba R, Wu Q, Saga Y, CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol. 2014 May 15;389(2):173-81
1	J:156651 Sarraj MA, Escalona RM, Umbers A, Chua HK, Small C, Griswold M, Loveland K, Findlay JK, Stenvers KL, Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice. Biol Reprod. 2010 Jan;82(1):153-62
1*	J:249183 Saxon JG, Baer DR, Barton JA, Hawkins T, Wu B, Trusk TC, Harris SE, Zhou B, Mishina Y, Sugi Y, BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling. Dev Biol. 2017 Oct 1;430(1):113-128
1	J:308861 Shendy NAM, Broadhurst AL, Shoemaker K, Read R, Abell AN, MAP3K4 kinase activity dependent control of mouse gonadal sex determination. Biol Reprod. 2021 Aug 3;105(2):491-502
1	J:333802 Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V, Modi D, LHX2 in germ cells control tubular organization in the developing mouse testis. Exp Cell Res. 2023 Feb 14;425(1):113511
1	J:324049 Singh N, Singh D, Bhide A, Sharma R, Sahoo S, Jolly MK, Modi D, Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary. Exp Cell Res. 2022 Jun 1;415(1):113108
1*	J:90282 Smith JM, Bowles J, Wilson M, Koopman P, HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Dev Dyn. 2004 Jun;230(2):366-70
1*	J:93161 Smith JM, Bowles J, Wilson M, Teasdale RD, Koopman P, Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expr Patterns. 2004 Oct;4(6):701-5
1*	J:221356 Snowball J, Ambalavanan M, Cornett B, Lang R, Whitsett J, Sinner D, Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Dev Biol. 2015 May 15;401(2):264-75
1*	J:225740 Snowball J, Ambalavanan M, Whitsett J, Sinner D, Endodermal Wnt signaling is required for tracheal cartilage formation. Dev Biol. 2015 Sep 1;405(1):56-70
1	J:343800 Souali-Crespo S, Condrea D, Vernet N, Feret B, Klopfenstein M, Grandgirard E, Alunni V, Cerciat M, Jung M, Mayere C, Nef S, Mark M, Chalmel F, Ghyselinck NB, Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24)
1	J:124088 Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. J Bone Miner Res. 2007 Aug;22(8):1260-70
1	J:171839 Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K, Rowley L, Eyre H, Rizzoti K, McAninch D, Goncalves J, Slee J, Turbitt E, Bruno D, Bengtsson H, Harley V, Vilain E, Sinclair A, Lovell-Badge R, Thomas P, Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest. 2011 Jan 4;121(1):328-41
1*	J:122361 Svingen T, Beverdam A, Bernard P, McClive P, Harley VR, Sinclair AH, Koopman P, Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Reproduction. 2007 May;133(5):983-9
1*	J:120357 Svingen T, Beverdam A, Verma P, Wilhelm D, Koopman P, Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation. Int J Dev Biol. 2007;51:255-258
1	J:262053 Tan Z, Niu B, Tsang KY, Melhado IG, Ohba S, He X, Huang Y, Wang C, McMahon AP, Jauch R, Chan D, Zhang MQ, Cheah KSE, Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. PLoS Genet. 2018 Apr;14(4):e1007346
1	J:143587 Tang H, Brennan J, Karl J, Hamada Y, Raetzman L, Capel B, Notch signaling maintains Leydig progenitor cells in the mouse testis. Development. 2008 Nov;135(22):3745-53
1*	J:336188 Terao M, Ogawa Y, Takada S, Kajitani R, Okuno M, Mochimaru Y, Matsuoka K, Itoh T, Toyoda A, Kono T, Jogahara T, Mizushima S, Kuroiwa A, Turnover of mammal sex chromosomes in the Sry-deficient Amami spiny rat is due to male-specific upregulation of Sox9. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2211574119
1	J:324297 Thomson E, Zhao L, Chen YS, Longmuss E, Ng ET, Sreenivasan R, Croft B, Song X, Sinclair A, Weiss M, Koopman P, Pelosi E, Generation and mutational analysis of a transgenic mouse model of human SRY. Hum Mutat. 2022 Mar;43(3):362-379
1	J:133934 Tomizuka K, Horikoshi K, Kitada R, Sugawara Y, Iba Y, Kojima A, Yoshitome A, Yamawaki K, Amagai M, Inoue A, Oshima T, Kakitani M, R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling. Hum Mol Genet. 2008 May 1;17(9):1278-91
1*	J:278064 Tsuji-Hosokawa A, Kashimada K, Kato T, Ogawa Y, Nomura R, Takasawa K, Lavery R, Coschiera A, Schlessinger D, Harley VR, Takada S, Morio T, Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development. Sci Rep. 2018 Sep 5;8(1):13263
1	J:203711 Wainwright EN, Jorgensen JS, Kim Y, Truong V, Bagheri-Fam S, Davidson T, Svingen T, Fernandez-Valverde SL, McClelland KS, Taft RJ, Harley VR, Koopman P, Wilhelm D, SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation. Biol Reprod. 2013 Aug;89(2):34
1*	J:216502 Wainwright EN, Svingen T, Ng ET, Wicking C, Koopman P, Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice. Dev Biol. 2014 Nov 15;395(2):342-54
1	J:321350 Warner DR, Wells JP, Greene RM, Pisano MM, Gene expression changes in the secondary palate and mandible of Prdm16(-/-) mice. Cell Tissue Res. 2013 Mar;351(3):445-52
1	J:292644 Whiley PAF, O'Donnell L, Moody SC, Handelsman DJ, Young JC, Richards EA, Almstrup K, Western PS, Loveland KL, Activin A Determines Steroid Levels and Composition in the Fetal Testis. Endocrinology. 2020 Jul 1;161(7)
1*	J:104307 Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS, The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas. Diabetes. 2005 Dec;54(12):3402-9
1	J:99574 Wilson MJ, Liaw L, Koopman P, Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn. 2005 Aug;233(4):1488-95
1	J:341382 Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y, Zhou B, Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
1	J:223223 Wu Q, Fukuda K, Weinstein M, Graff JM, Saga Y, SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice. Development. 2015 Feb 1;142(3):575-86
1	J:320420 Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu Y, Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. Dev Biol. 2022 Feb;482:91-100
1	J:326460 Yang R, Li R, Huang Z, Zuo Y, Yue H, Wu H, Gu F, Wang F, He M, Bian Z, Mycn deficiency underlies the development of orofacial clefts in mice and humans. Hum Mol Genet. 2022 Mar 3;31(5):803-815
1	J:177082 Yang Y, Chang BH, Yechoor V, Chen W, Li L, Tsai MJ, Chan L, The Kruppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice. Diabetologia. 2011 Oct;54(10):2595-605
1*	J:308927 Yoshida T, Matsuda M, Hirashima T, Incoherent Feedforward Regulation via Sox9 and ERK Underpins Mouse Tracheal Cartilage Development. Front Cell Dev Biol. 2020;8:585640
1	J:341147 Young RE, Jones MK, Hines EA, Li R, Luo Y, Shi W, Verheyden JM, Sun X, Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching. Dev Cell. 2020 Apr 6;53(1):73-85.e5
1*	J:240405 Zhao L, Arsenault M, Ng ET, Longmuss E, Chau TC, Hartwig S, Koopman P, SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice. Dev Biol. 2017 Mar 01;423(1):46-56
1	J:213934 Zhao L, Ng ET, Davidson TL, Longmuss E, Urschitz J, Elston M, Moisyadi S, Bowles J, Koopman P, Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11768-73
1	J:338076 Zhao L, Thomson E, Ng ET, Longmuss E, Svingen T, Bagheri-Fam S, Quinn A, Harley VR, Harrison LC, Pelosi E, Koopman P, Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice. Sex Dev. 2022;16(4):270-282