Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sox9  SRY (sex determining region Y)-box 9   (Synonyms: 2010306G03Rik)
Results	Reference
1	J:308132 Alankarage D, Lavery R, Svingen T, Kelly S, Ludbrook L, Bagheri-Fam S, Koopman P, Harley V, SOX9 regulates expression of the male fertility gene Ets variant factor 5 (ETV5) during mammalian sex development. Int J Biochem Cell Biol. 2016 Oct;79:41-51
1	J:247201 Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ, Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016 Jul 01;129(13):2493-9
1	J:104330 Barrionuevo F, Bagheri-Fam S, Klattig J, Kist R, Taketo MM, Englert C, Scherer G, Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice. Biol Reprod. 2006 Jan;74(1):195-201
1*	J:150223 Beverdam A, Svingen T, Bagheri-Fam S, Bernard P, McClive P, Robson M, Khojasteh MB, Salehi M, Sinclair AH, Harley VR, Koopman P, Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice. Reproduction. 2009 Mar;137(3):481-6
1*	J:164222 Beverdam A, Svingen T, Bagheri-Fam S, McClive P, Sinclair AH, Harley VR, Koopman P, Protein tyrosine kinase 2 beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads. Dev Dyn. 2010 Oct;239(10):2735-41
1	J:223863 Bhattaram P, Penzo-Mendez A, Kato K, Bandyopadhyay K, Gadi A, Taketo MM, Lefebvre V, SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis. J Cell Biol. 2014 Dec 8;207(5):657-71
1	J:335514 Bird AD, Frost ER, Bagheri-Fam S, Croft BM, Ryan JM, Zhao L, Koopman P, Harley VR, Somatic FGFR2 is Required for Germ Cell Maintenance in the Mouse Ovary. Endocrinology. 2023 Mar 13;164(5)
1*	J:93500 Bouma GJ, Hart GT, Washburn LL, Recknagel AK, Eicher EM, Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Gene Expr Patterns. 2004 Nov;5(1):141-9
1*	J:164280 Bowles J, Feng CW, Spiller C, Davidson TL, Jackson A, Koopman P, FGF9 suppresses meiosis and promotes male germ cell fate in mice. Dev Cell. 2010 Sep 14;19(3):440-9
1	J:149785 Bradford ST, Hiramatsu R, Maddugoda MP, Bernard P, Chaboissier MC, Sinclair A, Schedl A, Harley V, Kanai Y, Koopman P, Wilhelm D, The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice. Biol Reprod. 2009 Jun;80(6):1178-88
1	J:133933 Chassot AA, Ranc F, Gregoire EP, Roepers-Gajadien HL, Taketo MM, Camerino G, de Rooij DG, Schedl A, Chaboissier MC, Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum Mol Genet. 2008 May 1;17(9):1264-77
1	J:129651 Chi L, Itaranta P, Zhang S, Vainio S, Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis. Endocrinology. 2006 Aug;147(8):3777-88
1*	J:177793 Combes AN, Bowles J, Feng CW, Chiu HS, Khoo PL, Jackson A, Little MH, Tam PP, Koopman P, Expression and functional analysis of Dkk1 during early gonadal development. Sex Dev. 2011;5(3):124-30
1	J:158334 Combes AN, Spiller CM, Harley VR, Sinclair AH, Dunwoodie SL, Wilhelm D, Koopman P, Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation. Int J Dev Biol. 2010;54(4):683-9
1	J:325442 Dai H, Zhu M, Li W, Si G, Xing Y, Activation of PI3K/p110alpha in the Lung Mesenchyme Affects Branching Morphogenesis and Club Cell Differentiation. Front Cell Dev Biol. 2022;10:880206
1	J:159860 Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ, RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development. 2010 May;137(9):1461-71
1*	J:134429 Flagg AE, Earley JU, Svensson EC, FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Dev Biol. 2007 Apr 1;304(1):308-16
1	J:204550 Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R, Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
1*	J:314338 Gajjala PR, Kasam RK, Soundararajan D, Sinner D, Huang SK, Jegga AG, Madala SK, Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis. JCI Insight. 2021 Oct 22;6(20):e152503
1	J:175737 Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V, BMPR-II is dispensable for formation of the limb skeleton. Genesis. 2011 Sep;49(9):719-24
1	J:227703 Garside VC, Cullum R, Alder O, Lu DY, Vander Werff R, Bilenky M, Zhao Y, Jones SJ, Marra MA, Underhill TM, Hoodless PA, SOX9 modulates the expression of key transcription factors required for heart valve development. Development. 2015 Dec 15;142(24):4340-50
1*	J:238708 Gonen N, Quinn A, O'Neill HC, Koopman P, Lovell-Badge R, Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet. 2017 Jan;13(1):e1006520
1	J:167078 Gregoire EP, Lavery R, Chassot AA, Akiyama H, Treier M, Behringer RR, Chaboissier MC, Transient development of ovotestes in XX Sox9 transgenic mice. Dev Biol. 2011 Jan 1;349(1):65-77
1	J:240020 Herriges JC, Verheyden JM, Zhang Z, Sui P, Zhang Y, Anderson MJ, Swing DA, Zhang Y, Lewandoski M, Sun X, FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Dev Cell. 2015 Nov 09;35(3):322-32
1	J:270532 Iezaki T, Fukasawa K, Horie T, Park G, Robinson S, Nakaya M, Fujita H, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Yoneda Y, Takarada T, Guo XE, Kurose H, Hinoi E, The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis. Development. 2018 Jul 26;145(14):dev164004
1	J:289698 Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Manabe T, Ishigaki Y, Ohno M, Hinoi E, Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis. Stem Cell Reports. 2018 Jul 10;11(1):228-241
1	J:303384 Ikeda Y, Tagami A, Maekawa M, Nagai A, The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation. Sci Rep. 2021 Feb 24;11(1):4486
1	J:138181 Ikeda Y, Tanaka H, Esaki M, Effects of gestational diethylstilbestrol treatment on male and female gonads during early embryonic development. Endocrinology. 2008 Aug;149(8):3970-9
1	J:115338 Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y, Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 2006 Nov;133(22):4463-73
1	J:188056 Jameson SA, Lin YT, Capel B, Testis development requires the repression of Wnt4 by Fgf signaling. Dev Biol. 2012 Oct 1;370(1):24-32
1	J:277950 Kang HM, Huang S, Reidy K, Han SH, Chinga F, Susztak K, Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice. Cell Rep. 2016 Feb 2;14(4):861-871
1	J:178424 Kashimada K, Svingen T, Feng CW, Pelosi E, Bagheri-Fam S, Harley VR, Schlessinger D, Bowles J, Koopman P, Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J. 2011 Oct;25(10):3561-9
1	J:173702 Kim B, Kim Y, Cooke PS, Ruther U, Jorgensen JS, The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice. Biol Reprod. 2011 May;84(5):1024-32
1	J:185603 Li S, Wang Y, Zhang Y, Lu MM, Demayo FJ, Dekker JD, Tucker PW, Morrisey EE, Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 2012 Jul;139(14):2500-9
1	J:280419 Liberti DC, Zepp JA, Bartoni CA, Liberti KH, Zhou S, Lu M, Morley MP, Morrisey EE, Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate. Dev Biol. 2019 Oct 15;454(2):108-117
1*	J:84446 Lioubinski O, Muller M, Wegner M, Sander M, Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003 Jul;227(3):402-8
1	J:202899 Liu H, Lan Y, Xu J, Chang CF, Brugmann SA, Jiang R, Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18555-60
1	J:183814 Ludbrook LM, Bernard P, Bagheri-Fam S, Ryan J, Sekido R, Wilhelm D, Lovell-Badge R, Harley VR, Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9). Endocrinology. 2012 Apr;153(4):1948-58
1	J:267771 Mamidi A, Prawiro C, Seymour PA, de Lichtenberg KH, Jackson A, Serup P, Semb H, Mechanosignalling via integrins directs fate decisions of pancreatic progenitors. Nature. 2018 Dec;564(7734):114-118
1	J:122944 Manuylov NL, Fujiwara Y, Adameyko II, Poulat F, Tevosian SG, The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models. Dev Biol. 2007 Jul 15;307(2):356-67
1	J:229014 Marty-Santos L, Cleaver O, Pdx1 regulates pancreas tubulogenesis and E-cadherin expression. Development. 2016 Jan 1;143(1):101-12
1	J:149544 Moniot B, Declosmenil F, Barrionuevo F, Scherer G, Aritake K, Malki S, Marzi L, Cohen-Solal A, Georg I, Klattig J, Englert C, Kim Y, Capel B, Eguchi N, Urade Y, Boizet-Bonhoure B, Poulat F, The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. Development. 2009 Jun;136(11):1813-21
1*	J:176205 Moniot B, Farhat A, Aritake K, Declosmenil F, Nef S, Eguchi N, Urade Y, Poulat F, Boizet-Bonhoure B, Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein. Dev Dyn. 2011 Oct;240(10):2335-43
1	J:342643 Oh Y, Kasu M, Bottoms CJ, Douglas JC, Sekulovski N, Hayashi K, MacLean Ii JA, Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice. Biol Reprod. 2023 Oct 13;109(4):520-532
1	J:276812 Ortega EA, Salvador Q, Fernandez M, Ward MA, Alterations of sex determination pathways in the genital ridges of males with limited Y chromosome genes. Biol Reprod. 2019 Mar 1;100(3):810-823
1	J:172637 Park S, Zeidan K, Shin JS, Taketo T, SRY upregulation of SOX9 is inefficient and delayed, allowing ovarian differentiation, in the B6.Y(TIR) gonad. Differentiation. 2011 Jul;82(1):18-27
1*	J:222912 Parma P, Radi O, Vidal V, Chaboissier MC, Dellambra E, Valentini S, Guerra L, Schedl A, Camerino G, R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet. 2006 Nov;38(11):1304-9
1*	J:178075 Peacock JD, Huk DJ, Ediriweera HN, Lincoln J, Sox9 transcriptionally represses spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS One. 2011;6(10):e26769
1*	J:186533 Pennekamp P, Feldner S, Seesing FJ, Psathaki OE, Scholer HR, Wieacker P, Dworniczak B, Bcar3 is expressed in sertoli cells and germ cells of the developing testis in mice. Sex Dev. 2011;5(4):197-204
1	J:234328 Perez Millan MI, Brinkmeier ML, Mortensen AH, Camper SA, PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells. Elife. 2016;5:e14470
1	J:197599 Pitetti JL, Calvel P, Romero Y, Conne B, Truong V, Papaioannou MD, Schaad O, Docquier M, Herrera PL, Wilhelm D, Nef S, Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
1*	J:122569 Puri S, Hebrok M, Dynamics of embryonic pancreas development using real-time imaging. Dev Biol. 2007 Jun 1;306(1):82-93
1	J:247121 Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ, HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. J Cell Sci. 2016 Jun 01;129(11):2145-55
1*	J:209131 Saba R, Wu Q, Saga Y, CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol. 2014 May 15;389(2):173-81
1	J:171472 Sand FW, Hornblad A, Johansson JK, Loren C, Edsbagge J, Stahlberg A, Magenheim J, Ilovich O, Mishani E, Dor Y, Ahlgren U, Semb H, Growth-limiting role of endothelial cells in endoderm development. Dev Biol. 2011 Apr 15;352(2):267-77
1	J:156651 Sarraj MA, Escalona RM, Umbers A, Chua HK, Small C, Griswold M, Loveland K, Findlay JK, Stenvers KL, Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice. Biol Reprod. 2010 Jan;82(1):153-62
1	J:281204 Sen R, Pezoa SA, Carpio Shull L, Hernandez-Lagunas L, Niswander LA, Artinger KB, Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice. J Dev Biol. 2018 Nov 12;6(4)
1	J:208341 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B, Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
1	J:187729 Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M, A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep;139(18):3363-72
1	J:317430 Sharma D, Mirando AJ, Leinroth A, Long JT, Karner CM, Hilton MJ, HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. PLoS Genet. 2021 Dec;17(12):e1009982
1*	J:276703 Shi J, Gao Q, Cao Y, Fu J, Dennd1a, a susceptibility gene for polycystic ovary syndrome, is essential for mouse embryogenesis. Dev Dyn. 2019 May;248(5):351-362
1	J:239547 Sivakamasundari V, Kraus P, Sun W, Hu X, Lim SL, Prabhakar S, Lufkin T, A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development. Biol Open. 2017 Feb 15;6(2):187-199
1*	J:93161 Smith JM, Bowles J, Wilson M, Teasdale RD, Koopman P, Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expr Patterns. 2004 Oct;4(6):701-5
1*	J:225740 Snowball J, Ambalavanan M, Whitsett J, Sinner D, Endodermal Wnt signaling is required for tracheal cartilage formation. Dev Biol. 2015 Sep 1;405(1):56-70
1	J:124088 Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. J Bone Miner Res. 2007 Aug;22(8):1260-70
1	J:171839 Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K, Rowley L, Eyre H, Rizzoti K, McAninch D, Goncalves J, Slee J, Turbitt E, Bruno D, Bengtsson H, Harley V, Vilain E, Sinclair A, Lovell-Badge R, Thomas P, Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest. 2011 Jan 4;121(1):328-41
1	J:305205 Tang F, Richardson N, Albina A, Chaboissier MC, Perea-Gomez A, Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9. Cells. 2020 Apr 29;9(5):1103
1	J:325558 Torres-Cano A, Portella-Fortuny R, Muller-Sanchez C, Porras-Marfil S, Ramiro-Pareta M, Chau YY, Reina M, Soriano FX, Martinez-Estrada OM, Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice. PLoS Genet. 2022 Jun;18(6):e1010240
1*	J:116618 Vohra BP, Planer W, Armon J, Fu M, Jain S, Heuckeroth RO, Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Dev Dyn. 2007 Jan;236(1):106-17
1	J:158460 Vrljicak P, Chang AC, Morozova O, Wederell ED, Niessen K, Marra MA, Karsan A, Hoodless PA, Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal. Physiol Genomics. 2010 Feb 4;40(3):150-7
1	J:321350 Warner DR, Wells JP, Greene RM, Pisano MM, Gene expression changes in the secondary palate and mandible of Prdm16(-/-) mice. Cell Tissue Res. 2013 Mar;351(3):445-52
1	J:210362 Warr N, Siggers P, Carre GA, Bogani D, Brixey R, Akiyoshi M, Tachibana M, Teboul L, Wells S, Sanderson J, Greenfield A, Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice. Hum Mol Genet. 2014 Jun 1;23(11):3035-44
1	J:292644 Whiley PAF, O'Donnell L, Moody SC, Handelsman DJ, Young JC, Richards EA, Almstrup K, Western PS, Loveland KL, Activin A Determines Steroid Levels and Composition in the Fetal Testis. Endocrinology. 2020 Jul 1;161(7)
1*	J:103443 Wilhelm D, Martinson F, Bradford S, Wilson MJ, Combes AN, Beverdam A, Bowles J, Mizusaki H, Koopman P, Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol. 2005 Nov 1;287(1):111-24
1*	J:104307 Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS, The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas. Diabetes. 2005 Dec;54(12):3402-9
1	J:320185 Windley SP, Mayere C, McGovern AE, Harvey NL, Nef S, Schwarz Q, Kumar S, Wilhelm D, Loss of NEDD4 causes complete XY gonadal sex reversal in mice. Cell Death Dis. 2022 Jan 24;13(1):75
1	J:320420 Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu Y, Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. Dev Biol. 2022 Feb;482:91-100
1	J:326460 Yang R, Li R, Huang Z, Zuo Y, Yue H, Wu H, Gu F, Wang F, He M, Bian Z, Mycn deficiency underlies the development of orofacial clefts in mice and humans. Hum Mol Genet. 2022 Mar 3;31(5):803-815
1	J:242896 Yao C, Carraro G, Konda B, Guan X, Mizuno T, Chiba N, Kostelny M, Kurkciyan A, David G, McQualter JL, Stripp BR, Sin3a regulates epithelial progenitor cell fate during lung development. Development. 2017 Jul 15;144(14):2618-2628
1*	J:308927 Yoshida T, Matsuda M, Hirashima T, Incoherent Feedforward Regulation via Sox9 and ERK Underpins Mouse Tracheal Cartilage Development. Front Cell Dev Biol. 2020;8:585640
1	J:324215 Zhang Y, Yokoyama S, Herriges JC, Zhang Z, Young RE, Verheyden JM, Sun X, E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7557-62