Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fgf8  fibroblast growth factor 8   (Synonyms: Aigf, Fgf-8)
Results	Reference
1	J:333368 Aldea D, Kokalari B, Atsuta Y, Dingwall HL, Zheng Y, Nace A, Cotsarelis G, Kamberov YG, Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development. PLoS Genet. 2023 Feb;19(2):e1010614
1	J:189073 Benazet JD, Pignatti E, Nugent A, Unal E, Laurent F, Zeller R, Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development. 2012 Nov;139(22):4250-60
1	J:220864 Billmyre KK, Klingensmith J, Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. Dev Dyn. 2015 Apr;244(4):564-76
1*	J:38677 Blunt AG, Lawshe A, Cunningham ML, Seto ML, Ornitz DM, MacArthur CA, Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands. J Biol Chem. 1997 Feb 7;272(6):3733-8
1	J:161416 Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG, Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15;342(2):169-79
1	J:214092 Firulli BA, Fuchs RK, Vincentz JW, Clouthier DE, Firulli AB, Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development. 2014 Aug;141(15):3050-61
1	J:198516 Fujita K, Taya Y, Shimazu Y, Aoba T, Soeno Y, Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family. Int J Dev Biol. 2013;57(5):399-406
1*	J:96841 Gong SG, Gong TW, Shum L, Identification of markers of the midface. J Dent Res. 2005 Jan;84(1):69-72
1	J:217408 Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrimsson B, Williams T, Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Dis Model Mech. 2015 Jan;8(1):31-43
1	J:259795 Green RM, Fish JL, Young NM, Smith FJ, Roberts B, Dolan K, Choi I, Leach CL, Gordon P, Cheverud JM, Roseman CC, Williams TJ, Marcucio RS, Hallgrimsson B, Developmental nonlinearity drives phenotypic robustness. Nat Commun. 2017 Dec 6;8(1):1970
1	J:152574 High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA, Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest. 2009 Jul;119(7):1986-96
1	J:300883 Hornblad A, Bastide S, Langenfeld K, Langa F, Spitz F, Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy. Nat Commun. 2021 Jan 19;12(1):439
1	J:158677 Huh SH, Ornitz DM, Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development. 2010 Apr;137(7):1137-47
1	J:184014 Jin YR, Han XH, Taketo MM, Yoon JK, Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development. 2012 May;139(10):1821-30
1*	J:200761 Kasberg AD, Brunskill EW, Steven Potter S, SP8 regulates signaling centers during craniofacial development. Dev Biol. 2013 Sep 15;381(2):312-23
1	J:243551 Kataoka K, Matsushima T, Ito Y, Sato T, Yokoyama S, Asahara H, Bhlha9 regulates apical ectodermal ridge formation during limb development. J Bone Miner Metab. 2018 Jan;36(1):64-72
1	J:245137 Kawata M, Taniguchi Y, Mori D, Yano F, Ohba S, Chung UI, Shimogori T, Mills AA, Tanaka S, Saito T, Different regulation of limb development by p63 transcript variants. PLoS One. 2017;12(3):e0174122
1	J:103123 Kawauchi S, Shou J, Santos R, Hebert JM, McConnell SK, Mason I, Calof AL, Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development. 2005 Dec;132(23):5211-23
1	J:174086 Layman WS, Hurd EA, Martin DM, Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome. Hum Mol Genet. 2011 Aug 15;20(16):3138-50
1	J:279721 Linscott ML, Chung WCJ, TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons. PLoS One. 2019;14(7):e0220530
1	J:317599 Ma HY, Xu J, Eng D, Gross MK, Kioussi C, Pitx2-mediated cardiac outflow tract remodeling. Dev Dyn. 2013 May;242(5):456-68
1	J:88806 Marikawa Y, Fujita TC, Alarcon VB, An enhancer-trap LacZ transgene reveals a distinct expression pattern of Kinesin family 26B in mouse embryos. Dev Genes Evol. 2004 Feb;214(2):64-71
1	J:196292 Marinic M, Aktas T, Ruf S, Spitz F, An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Dev Cell. 2013 Mar 11;24(5):530-42
1	J:310909 Miao L, Lu Y, Nusrat A, Abdelnasser HY, Datta S, Zhou B, Schwartz RJ, Wu M, The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis. Cells. 2021 Aug 25;10(9)
1	J:256374 Ogoh H, Yamagata K, Nakao T, Sandell LL, Yamamoto A, Yamashita A, Tanga N, Suzuki M, Abe T, Kitabayashi I, Watanabe T, Sakai D, Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development. Sci Rep. 2017 Sep 20;7(1):11922
1*	J:74134 Pickles JO, The expression of fibroblast growth factors and their receptors in the embryonic and neonatal mouse inner ear. Hear Res. 2001 May;155(1-2):54-62
1	J:154590 Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett AN, Vitelli F, Prescott K, Shaw-Smith C, Devriendt K, Bosman E, Steffes G, Steel KP, Simrick S, Basson MA, Illingworth E, Scambler PJ, Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest. 2009 Nov;119(11):3301-10
1	J:168016 Reid BS, Yang H, Melvin VS, Taketo MM, Williams T, Ectodermal Wnt/beta-catenin signaling shapes the mouse face. Dev Biol. 2011 Jan 15;349(2):261-9
1	J:44985 Seto ML, Nunes ME, MacArthur CA, Cunningham ML, Pathogenesis of ectrodactyly in the Dactylaplasia mouse: aberrant cell death of the apical ectodermal ridge. Teratology. 1997 Oct;56(4):262-70
1	J:229011 Yakushiji-Kaminatsui N, Kondo T, Endo TA, Koseki Y, Kondo K, Ohara O, Vidal M, Koseki H, RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression. Development. 2016 Jan 15;143(2):276-85
1	J:171767 Zhang W, Hong M, Bae GU, Kang JS, Krauss RS, Boc modifies the holoprosencephaly spectrum of Cdo mutant mice. Dis Model Mech. 2011 May-Jun;4(3):368-80
1	J:310132 Zhou L, Liu J, Olson P, Zhang K, Wynne J, Xie L, Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation. J Mol Cell Cardiol. 2015 Aug;85:1-12
1*	J:229317 Zhu XJ, Liu Y, Yuan X, Wang M, Zhao W, Yang X, Zhang X, Hsu W, Qiu M, Zhang Z, Zhang Z, Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis. Dev Dyn. 2016 Mar;245(3):414-26