Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pitx2  paired-like homeodomain transcription factor 2   (Synonyms: Brx1, Brx1a, Brx1b, Munc30, Otlx2, Pitx2a, Pitx2b, Pitx2c, Ptx2, Rieg, solurshin)
Results	Reference
1	J:193588 Ammirabile G, Tessari A, Pignataro V, Szumska D, Sutera Sardo F, Benes J Jr, Balistreri M, Bhattacharya S, Sedmera D, Campione M, Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium. Cardiovasc Res. 2012 Feb 1;93(2):291-301
1*	J:47444 Arakawa H, Nakamura T, Zhadanov AB, Fidanza V, Yano T, Bullrich F, Shimizu M, Blechman J, Mazo A, Canaani E, Croce CM, Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4573-8
1	J:341993 Bernheim S, Borgel A, Le Garrec JF, Perthame E, Desgrange A, Michel C, Guillemot L, Sart S, Baroud CN, Krezel W, Raimondi F, Bonnet D, Zaffran S, Houyel L, Meilhac SM, Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells. Dev Cell. 2023 Oct 13;
1	J:169150 Bharti K, Gasper M, Bertuzzi S, Arnheiter H, Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary. Development. 2011 Mar;138(5):873-8
1*	J:193413 Bildsoe H, Loebel DA, Jones VJ, Hor AC, Braithwaite AW, Chen YT, Behringer RR, Tam PP, The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Dev Biol. 2013 Feb 15;374(2):295-307
1	J:169235 Carbe C, Zhang X, Lens induction requires attenuation of ERK signaling by Nf1. Hum Mol Genet. 2011 Apr 1;20(7):1315-23
1	J:245758 Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP, Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
1*	J:56581 Daubas P, Tajbakhsh S, Hadchouel J, Primig M, Buckingham M, Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons. Development. 2000 Jan;127(2):319-31
1	J:231503 Gergics P, Brinkmeier ML, Camper SA, Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia. Mol Endocrinol. 2015 Apr;29(4):597-612
1	J:80691 Kioussi C, Briata P, Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J, Brault V, Ruiz-Lozano P, Nguyen HD, Kemler R, Glass CK, Wynshaw-Boris A, Rosenfeld MG, Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development. Cell. 2002 Nov 27;111(5):673-85
1*	J:43579 Kitamura K, Miura H, Yanazawa M, Miyashita T, Kato K, Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation. Mech Dev. 1997 Sep;67(1):83-96
1	J:92817 Li S, Zhou D, Lu MM, Morrisey EE, Advanced cardiac morphogenesis does not require heart tube fusion. Science. 2004 Sep 10;305(5690):1619-22
1*	J:79853 Liu C, Liu W, Palie J, Lu MF, Brown NA, Martin JF, Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
1*	J:99697 Liu W, Selever J, Murali D, Sun X, Brugger SM, Ma L, Schwartz RJ, Maxson R, Furuta Y, Martin JF, Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol. 2005 Jul 15;283(2):282-93
1*	J:80521 Martin DM, Skidmore JM, Fox SE, Gage PJ, Camper SA, Pitx2 distinguishes subtypes of terminally differentiated neurons in the developing mouse neuroepithelium. Dev Biol. 2002 Dec 1;252(1):84-99
1	J:141338 Mommersteeg MT, Brown NA, Prall OW, de Gier-de Vries C, Harvey RP, Moorman AF, Christoffels VM, Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ Res. 2007 Oct 26;101(9):902-9
1*	J:77401 Pennekamp P, Karcher C, Fischer A, Schweickert A, Skryabin B, Horst J, Blum M, Dworniczak B, The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol. 2002 Jun 4;12(11):938-43
1	J:185652 Qu X, Pan Y, Carbe C, Powers A, Grobe K, Zhang X, Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development. 2012 Aug;139(15):2730-9
1*	J:156467 Saxena A, Tabin CJ, miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):87-91
1	J:53310 Szeto DP, Rodriguez-Esteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisua-Belmonte JC, Rosenfeld MG, Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev. 1999 Feb 15;13(4):484-94
1	J:147648 Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M, Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Circ Res. 2008 Apr 11;102(7):813-22
1	J:189488 Waite MR, Skaggs K, Kaviany P, Skidmore JM, Causeret F, Martin JF, Martin DM, Distinct populations of GABAergic neurons in mouse rhombomere 1 express but do not require the homeodomain transcription factor PITX2. Mol Cell Neurosci. 2012 Jan;49(1):32-43
1	J:196616 Willaredt MA, Gorgas K, Gardner HA, Tucker KL, Multiple essential roles for primary cilia in heart development. Cilia. 2012;1(1):23
1*	J:327901 Ye Q, Bhojwani A, Hu JK, Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
1	J:168032 Zacharias AL, Lewandoski M, Rudnicki MA, Gage PJ, Pitx2 is an upstream activator of extraocular myogenesis and survival. Dev Biol. 2011 Jan 15;349(2):395-405
1	J:197830 Zhang R, Huang H, Cao P, Wang Z, Chen Y, Pan Y, Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem. 2013 Apr 12;288(15):10275-85