Gene Expression Literature Summary

• Symbol: Edn1
• Name: endothelin 1
• ID: MGI:95283

60 matching records from 60 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	P
Immunohistochemistry (section)					1			1								1				1		2
In situ RNA (section)		2	5	2	4		6	3	4		4				1				2			1
Immunohistochemistry (whole mount)													1
In situ RNA (whole mount)	1	2	7	2	1		1
Northern blot										1				1		2		1	1	1		2
Western blot					1			1
RT-PCR		1	3		5	1	3	3	1	2		2	2	2		3	1	1	1	1	1	16
cDNA clones																						2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Edn1  endothelin 1   (Synonyms: ET-1)
Results	Reference
4	J:167203 Baragatti B, Ciofini E, Scebba F, Angeloni D, Sodini D, Luin S, Ratto GM, Ottaviano V, Pagni E, Paolicchi A, Nencioni S, Coceani F, Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice. Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H892-901
2	J:229471 Branchfield K, Nantie L, Verheyden JM, Sui P, Wienhold MD, Sun X, Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12;351(6274):707-10
7*	J:31149 Chan TS, Lin CX, Chan WY, Chung SS, Chung SK, Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development. Eur J Biochem. 1995 Dec 15;234(3):819-26
1	J:194534 Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E, NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature. 2013 Mar 7;495(7439):98-102
1	J:201436 Chang I, Bramall AN, Baynash AG, Rattner A, Rakheja D, Post M, Joza S, McKerlie C, Stewart DJ, McInnes RR, Yanagisawa M, Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
1	J:206313 Chiplunkar AR, Curtis BC, Eades GL, Kane MS, Fox SJ, Haar JL, Lloyd JA, The Kruppel-like factor 2 and Kruppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis. BMC Dev Biol. 2013;13:40
1*	J:46639 Clouthier DE, Hosoda K, Richardson JA, Williams SC, Yanagisawa H, Kuwaki T, Kumada M, Hammer RE, Yanagisawa M, Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development. 1998 Mar;125(5):813-24
2*	J:306181 Crosse EI, Gordon-Keylock S, Rybtsov S, Binagui-Casas A, Felchle H, Nnadi NC, Kirschner K, Chandra T, Tamagno S, Webb DJ, Rossi F, Anderson RA, Medvinsky A, Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development. Cell Stem Cell. 2020 Nov 5;27(5):822-839.e8
2	J:241786 Darwich R, Li W, Yamak A, Komati H, Andelfinger G, Sun K, Nemer M, KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5. Hum Mol Genet. 2017 Mar 01;26(5):942-954
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:213691 Donato AJ, Lesniewski LA, Stuart D, Walker AE, Henson G, Sorensen L, Li D, Kohan DE, Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development. Life Sci. 2014 Nov 24;118(2):238-43
3	J:267941 Fakhouri WD, Metwalli K, Naji A, Bakhiet S, Quispe-Salcedo A, Nitschke L, Kousa YA, Schutte BC, Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development. Sci Rep. 2017 Aug 2;7(1):7129
1	J:148046 Fogelgren B, Yang S, Sharp IC, Huckstep OJ, Ma W, Somponpun SJ, Carlson EC, Uyehara CF, Lozanoff S, Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice. Am J Physiol Renal Physiol. 2009 May;296(5):F1166-78
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:299975 Gharibeh L, Yamak A, Whitcomb J, Lu A, Joyal M, Komati H, Liang W, Fiset C, Nemer M, GATA6 is a regulator of sinus node development and heart rhythm. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2007322118
1	J:91658 Gitler AD, Lu MM, Epstein JA, PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004 Jul;7(1):107-16
1	J:191738 Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, Leviatan N, Hegesh J, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E, Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44
3	J:207974 Hill CR, Yuasa M, Schoenecker J, Goudy SL, Jagged1 is essential for osteoblast development during maxillary ossification. Bone. 2014 May;62:10-21
1	J:89220 Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamizu A, Federoff HJ, Ogawa S, Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest. 2004 Apr;113(6):876-84
3*	J:152650 Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D, Transcriptional regulation during development of the ductus arteriosus. Circ Res. 2008 Aug 15;103(4):388-95
1	J:101263 Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ, Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol. 2005 Sep 15;285(2):554-69
2	J:171482 Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK, The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Dev Biol. 2011 Apr 1;352(1):1-13
1	J:263568 Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH, LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res. 2015 Oct 1;108(1):197-208
2*	J:79898 Kochilas L, Merscher-Gomez S, Lu MM, Potluri V, Liao J, Kucherlapati R, Morrow B, Epstein JA, The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol. 2002 Nov 1;251(1):157-66
2*	J:99326 Kuhnert F, Campagnolo L, Xiong JW, Lemons D, Fitch MJ, Zou Z, Kiosses WB, Gardner H, Stuhlmann H, Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol. 2005 Jul 1;283(1):140-156
1	J:333327 Kurihara Y, Ekimoto T, Gordon CT, Uchijima Y, Sugiyama R, Kitazawa T, Iwase A, Kotani R, Asai R, Pingault V, Ikeguchi M, Amiel J, Kurihara H, Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding. J Clin Invest. 2023 Feb 15;133(4)
4*	J:26778 Kurihara Y, Kurihara H, Oda H, Maemura K, Nagai R, Ishikawa T, Yazaki Y, Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1 [see comments]. J Clin Invest. 1995 Jul;96(1):293-300
3*	J:17694 Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, Oda H, Kuwaki T, Cao WH, Kamada N, Jishage K, Ouchi Y, Azuma S, Toyoda Y, Ishikawa T, Kumada M, Yazaki Y, Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1 [see comments]. Nature. 1994 Apr 21;368(6473):703-10
1	J:127228 Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML, Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006 Dec;11(6):845-57
1	J:87220 Liu W, Selever J, Lu MF, Martin JF, Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development. 2003 Dec;130(25):6375-85
1	J:242127 Liu Z, Li W, Ma X, Ding N, Spallotta F, Southon E, Tessarollo L, Gaetano C, Mukouyama YS, Thiele CJ, Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development. J Biol Chem. 2014 Oct 24;289(43):29801-16
1*	J:30606 Maemura K, Kurihara H, Kurihara Y, Kuwaki T, Kumada M, Yazaki Y, Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S17-21
4*	J:31183 Maemura K, Kurihara H, Kurihara Y, Oda H, Ishikawa T, Copeland NG, Gilbert DJ, Jenkins NA, Yazaki Y, Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene. Genomics. 1996 Jan 15;31(2):177-84
2	J:258670 Mahany EB, Han X, Borges BC, da Silveira Cruz-Machado S, Allen SJ, Garcia-Galiano D, Hoenerhoff MJ, Bellefontaine NH, Elias CF, Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733
3*	J:133765 Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD, Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008 Apr 10;452(7188):759-63
1	J:114175 Mallo M, Schrewe H, Martin JF, Olson EN, Ohnemus S, Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium. Development. 2000 Oct;127(19):4127-36
1	J:191676 Manceau V, Kremmer E, Nabel EG, Maucuer A, The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
1	J:250662 Manousiouthakis E, Mendez M, Garner MC, Exertier P, Makita T, Venous endothelin guides sympathetic innervation of the developing mouse heart. Nat Commun. 2014 May 29;5:3918
1	J:258361 McCulley DJ, Wienhold MD, Hines EA, Hacker TA, Rogers A, Pewowaruk RJ, Zewdu R, Chesler NC, Selleri L, Sun X, PBX transcription factors drive pulmonary vascular adaptation to birth. J Clin Invest. 2018 Feb 1;128(2):655-667
1*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
1	J:194919 Nam J, Onitsuka I, Hatch J, Uchida Y, Ray S, Huang S, Li W, Zang H, Ruiz-Lozano P, Mukouyama YS, Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development. 2013 Apr;140(7):1475-85
1	J:345597 Quilez S, Dumontier E, Baim C, Kam J, Cloutier JF, Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465
6*	J:37680 Reid K, Turnley AM, Maxwell GD, Kurihara Y, Kurihara H, Bartlett PF, Murphy M, Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development. 1996 Dec;122(12):3911-9
1	J:224515 Sato T, Kurihara Y, Asai R, Kawamura Y, Tonami K, Uchijima Y, Heude E, Ekker M, Levi G, Kurihara H, An endothelin-1 switch specifies maxillomandibular identity. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18806-11
1*	J:236098 Shin J, Salameh JS, Richter JD, Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration. Sci Rep. 2016 Jul 06;6:29395
3	J:181632 Sun Y, Teng I, Huo R, Rosenfeld MG, Olson LE, Li X, Li X, Asymmetric requirement of surface epithelial beta-catenin during the upper and lower jaw development. Dev Dyn. 2012 Apr;241(4):663-74
3*	J:221133 Tavares AL, Clouthier DE, Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders. Dev Biol. 2015 Apr 15;400(2):191-201
2	J:241567 Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE, Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 Jun 01;144(11):2021-2031
1*	J:49658 Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN , Srivastava D, A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development. 1998 Aug;125(16):3005-14
4*	J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
1	J:58999 Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR, Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 1;13(23):3136-48
3*	J:80864 Uchide T, Fujimori Y, Sasaki T, Temma K, Adur J, Masuo Y, Kozakai T, Lee YS, Saida K, Expression of endothelin-1 and vasoactive intestinal contractor genes in mouse organs during the perinatal period. Clin Sci (Lond). 2002 Aug;103 Suppl 48:167S-170S
4*	J:54819 Uchide T, Masuda H, Mitsui Y, Saida K, Gene expression of vasoactive intestinal contractor/endothelin-2 in ovary, uterus and embryo: comprehensive gene expression profiles of the endothelin ligand-receptor system revealed by semi-quantitative reverse transcription-polymerase chain reaction analysis in adult mouse tissues and during late embryonic development. J Mol Endocrinol. 1999 Apr;22(2):161-71
2	J:163514 Vieux-Rochas M, Mantero S, Heude E, Barbieri O, Astigiano S, Couly G, Kurihara H, Levi G, Merlo GR, Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw. Genesis. 2010 Jun;48(6):262-373
1*	J:57677 Winnier GE, Kume T, Deng K, Rogers R, Bundy J, Raines C, Walter MA, Hogan BL, Conway SJ, Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev Biol. 1999 Sep 15;213(2):418-31
3	J:132655 Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fujii-Kuriyama Y, Poellinger L, Yamamoto M, Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS. Mol Cell Biol. 2008 Feb;28(4):1285-97
1	J:48566 Yanagisawa H, Hammer RE, Richardson JA, Williams SC, Clouthier DE, Yanagisawa M, Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice [see comments]. J Clin Invest. 1998 Jul 1;102(1):22-33
1	J:317198 Yang Y, Paivinen P, Xie C, Krup AL, Makela TP, Mostov KE, Reiter JF, Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation. Nat Commun. 2021 Dec 10;12(1):7186
2	J:227211 Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD, Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186
2	J:268403 Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B, Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147