Gene Expression Literature Summary

• Symbol: Syna
• Name: syncytin a
• ID: MGI:2684898

44 matching records from 44 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)		1		1										1	1
In situ RNA (section)	1	7	1	2	3	1	2		3	1				1	10
Western blot							1								1
RT-PCR	2	4		7	6	7	6	4	7	3	4	3	5	1	18

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Syna  syncytin a   (Synonyms: Gm52, syncytin-A)
Results	Reference
3	J:335233 Astrof S, Arriagada C, Saijoh Y, Francou A, Kelly RG, Moon A, Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. Dev Biol. 2023 Apr 14;499:10-21
9*	J:253345 Bacquin A, Bireau C, Tanguy M, Romanet C, Vernochet C, Dupressoir A, Heidmann T, A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A. J Virol. 2017 Sep 15;91(18)
2	J:307822 Beal R, Alonso-Carriazo Fernandez A, Grammatopoulos DK, Matter K, Balda MS, ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis. Front Cell Dev Biol. 2021;9:658006
2	J:293009 Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S, Atypical protein kinase C iota (PKClambda/iota) ensures mammalian development by establishing the maternal-fetal exchange interface. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14280-14291
1	J:239317 Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK, Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. Differentiation. 2017 Mar - Apr;94:8-20
1	J:229091 Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W, Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016 Jan 25;36(2):152-63
2	J:182838 Chen X, Liu Z, Xu J, The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol. 2010 Oct;24(10):1917-34
2	J:239386 Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim OA, Sotlar K, Schurmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T, Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife. 2016 Dec 19;5:e20914
2*	J:288988 Coudert AE, Redelsperger F, Chabbi-Achengli Y, Vernochet C, Marty C, Decrouy X, Heidmann T, de Vernejoul MC, Dupressoir A, Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice. Bone Rep. 2019 Dec;11:100214
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:150813 Dupressoir A, Vernochet C, Bawa O, Harper F, Pierron G, Opolon P, Heidmann T, Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12127-32
8	J:180242 Dupressoir A, Vernochet C, Harper F, Guegan J, Dessen P, Pierron G, Heidmann T, A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73
2*	J:200767 Hughes M, Natale BV, Simmons DG, Natale DR, Ly6e expression is restricted to syncytiotrophoblast cells of the mouse placenta. Placenta. 2013 Sep;34(9):831-5
2	J:173620 Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B, p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth. Development. 2011 Jun;138(11):2235-47
1	J:190464 Keniry A, Oxley D, Monnier P, Kyba M, Dandolo L, Smits G, Reik W, The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat Cell Biol. 2012 Jul;14(7):659-65
2	J:294595 Koppes E, Shaffer B, Sadovsky E, Himes K, Barak Y, Sadovsky Y, Chaillet JR, Klf14 is an imprinted transcription factor that regulates placental growth. Placenta. 2019 Dec;88:61-67
2	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
4	J:169855 Kroger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM, Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol. 2011 Apr;178(4):1578-90
4	J:242904 Lacko LA, Hurtado R, Hinds S, Poulos MG, Butler JM, Stuhlmann H, Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function. Development. 2017 Jul 01;144(13):2469-2479
4	J:263810 Langford MB, Outhwaite JE, Hughes M, Natale DRC, Simmons DG, Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice. Sci Rep. 2018 Mar 2;8(1):3961
3	J:323371 Lee JG, Kim G, Park SG, Yon JM, Yeom J, Song HE, Cheong SA, Lim JS, Sung YH, Kim K, Yoo HJ, Hong EJ, Nam KH, Seong JK, Kim CJ, Nam SY, Baek IJ, Lipid signatures reflect the function of the murine primary placentation. Biol Reprod. 2022 Mar 19;106(3):583-596
1	J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
2	J:305960 Li F, Xu R, Lin CL, Low BE, Cai L, Li S, Ji P, Huang L, Wiles MV, Hannun YA, Obeid LM, Chen Y, Mao C, Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB J. 2020 Nov;34(11):15252-15268
3	J:197681 Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, Leone G, Cross JC, Wang H, A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 2013;11(4):e1001536
4	J:311847 Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T, Identification of a link between Wnt/beta-catenin signalling and the cell fusion pathway. Nat Commun. 2011 Nov 22;2:548
2	J:170637 Oh-McGinnis R, Bogutz AB, Lefebvre L, Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction. Dev Biol. 2011 Mar 15;351(2):277-86
2	J:286013 Outhwaite JE, Patel J, Simmons DG, Secondary Placental Defects in Cxadr Mutant Mice. Front Physiol. 2019;10:622
1	J:239786 Rakoczy J, Zhang Z, Bowling FG, Dawson PA, Simmons DG, Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015 Nov;25(11):1273-6
2	J:194978 Reichmann J, Reddington JP, Best D, Read D, Ollinger R, Meehan RR, Adams IR, The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice. Hum Mol Genet. 2013 May 1;22(9):1791-806
8	J:296367 Roberts GAG, Tunster SJ, Characterising the dynamics of placental glycogen stores in the mouse. Placenta. 2020 Sep 15;99:131-140
3	J:320731 Sandovici I, Georgopoulou A, Perez-Garcia V, Hufnagel A, Lopez-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constancia M, The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Dev Cell. 2022 Jan 10;57(1):63-79.e8
2	J:262281 Sarkar AA, Sabatino JA, Sugrue KF, Zohn IE, Abnormal labyrinthine zone in the Hectd1-null placenta. Placenta. 2016 Feb;38:16-23
2	J:132413 Schubert SW, Lamoureux N, Kilian K, Klein-Hitpass L, Hashemolhosseini S, Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1. J Biol Chem. 2008 Feb 29;283(9):5460-5
6*	J:136716 Simmons DG, Natale DR, Begay V, Hughes M, Leutz A, Cross JC, Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development. 2008 Jun;135(12):2083-91
1	J:174237 Sripathy S, Lee M, Vasioukhin V, Mammalian Llgl2 Is Necessary for Proper Branching Morphogenesis during Placental Development. Mol Cell Biol. 2011 Jul;31(14):2920-33
2	J:163273 Stemmler MP, Bedzhov I, A Cdh1HA knock-in allele rescues the Cdh1-/- phenotype but shows essential Cdh1 function during placentation. Dev Dyn. 2010 Sep;239(9):2330-44
2	J:221394 Szabo R, Peters DE, Kosa P, Camerer E, Bugge TH, Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet. 2014 Jul;10(7):e1004470
2	J:315981 Torregrosa-Carrion R, Pineiro-Sabaris R, Siguero-Alvarez M, Grego-Bessa J, Luna-Zurita L, Fernandes VS, MacGrogan D, Stainier DYR, de la Pompa JL, Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Sci Adv. 2021 Nov 12;7(46):eabj5445
1	J:228795 Tunster SJ, Creeth HD, John RM, The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Dev Biol. 2016 Jan 1;409(1):251-60
1	J:236398 Tunster SJ, McNamara GI, Creeth HD, John RM, Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. Dev Biol. 2016 Oct 1;418(1):55-65
3	J:267708 Tunster SJ, Van de Pette M, Creeth HDJ, Lefebvre L, John RM, Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Dis Model Mech. 2018 Nov 16;11(11):dmm035832
2*	J:177542 Tunster SJ, Van de Pette M, John RM, Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Dis Model Mech. 2011 Nov;4(6):814-21
1*	J:177109 Watson ED, Hughes M, Simmons DG, Natale DR, Sutherland AE, Cross JC, Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development. Dev Dyn. 2011 Nov;240(11):2505-19
2	J:316777 Wilkinson AL, Menelaou K, Rakoczy J, Tan XS, Watson ED, Disruption of Folate Metabolism Causes Poor Alignment and Spacing of Mouse Conceptuses for Multiple Generations. Front Cell Dev Biol. 2021;9:723978