Gene Expression Literature Summary

• Symbol: Ccm2
• Name: cerebral cavernous malformation 2
• ID: MGI:2384924

10 matching records from 10 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E4	E9	E9.5	E10.5	E13.5	E14.5	E15.5	E17.5	E	P
Immunohistochemistry (section)										1	1	1	1		1
In situ RNA (section)								1	1		2				1
Immunohistochemistry (whole mount)	1	1	1	1	1	1
In situ reporter (knock in)									1
Northern blot								1
Western blot								1						2	1
RT-PCR	1	1	1	1	1	1	1		1					1	2
cDNA clones															1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ccm2  cerebral cavernous malformation 2   (Synonyms: MGC:37115)
Results	Reference
3	J:146210 Boulday G, Blecon A, Petit N, Chareyre F, Garcia LA, Niwa-Kawakita M, Giovannini M, Tournier-Lasserve E, Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations. Dis Model Mech. 2009 Mar;2(3-4):168-77
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:201629 Faurobert E, Rome C, Lisowska J, Manet-Dupe S, Boulday G, Malbouyres M, Balland M, Bouin AP, Keramidas M, Bouvard D, Coll JL, Ruggiero F, Tournier-Lasserve E, Albiges-Rizo C, CCM1-ICAP-1 complex controls beta1 integrin-dependent endothelial contractility and fibronectin remodeling. J Cell Biol. 2013 Aug 5;202(3):545-61
13*	J:119912 Fong B, Watson PH, Watson AJ, Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation. BMC Dev Biol. 2007;7:2
1	J:265042 Han R, Pacifici M, Iwamoto M, Trojanowska M, Endothelial Erg expression is required for embryogenesis and vascular integrity. Organogenesis. 2015;11(2):75-86
1	J:171969 He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W, Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal. 2010;3(116):ra26
3	J:146528 Kleaveland B, Zheng X, Liu JJ, Blum Y, Tung JJ, Zou Z, Chen M, Guo L, Lu MM, Zhou D, Kitajewski J, Affolter M, Ginsberg MH, Kahn ML, Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med. 2009 Feb;15(2):169-76
4*	J:109566 Petit N, Blecon A, Denier C, Tournier-Lasserve E, Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development. Gene Expr Patterns. 2006 Jun;6(5):495-503
1	J:146527 Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, Mayo AH, Drakos SG, Marchuk DA, Davis GE, Li DY, The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med. 2009 Feb;15(2):177-84
6*	J:309492 Yaba A, Ordueri NE, Tanriover G, Sahin P, Demir N, Celik-Ozenci C, Expression of CCM2 and CCM3 during mouse gonadogenesis. J Assist Reprod Genet. 2015 Oct;32(10):1497-507