Gene Expression Literature Summary

• Symbol: Ctsq
• Name: cathepsin Q
• ID: MGI:2137385

40 matching records from 40 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17	E17.5	E18.5	E19.5	E	P
In situ RNA (section)		1		2		2	5		4		2		1	2			7
Northern blot	1		1	1		1		1		1			1		1		1
RT-PCR	1		2	6	1	8	6	4	9	2	3	1	4	6		2	18
cDNA clones															1		2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ctsq  cathepsin Q   (Synonyms: 1600010J02Rik)
Results	Reference
2	J:335233 Astrof S, Arriagada C, Saijoh Y, Francou A, Kelly RG, Moon A, Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. Dev Biol. 2023 Apr 14;499:10-21
1	J:239317 Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK, Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. Differentiation. 2017 Mar - Apr;94:8-20
2	J:182838 Chen X, Liu Z, Xu J, The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol. 2010 Oct;24(10):1917-34
1	J:144707 Chiu SY, Asai N, Costantini F, Hsu W, SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 2008 Dec 16;6(12):e310
11*	J:74618 Deussing J, Kouadio M, Rehman S, Werber I, Schwinde A, Peters C, Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Genomics. 2002 Feb;79(2):225-40
3	J:150813 Dupressoir A, Vernochet C, Bawa O, Harper F, Pierron G, Opolon P, Heidmann T, Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12127-32
8	J:180242 Dupressoir A, Vernochet C, Harper F, Guegan J, Dessen P, Pierron G, Heidmann T, A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73
1	J:249801 Duval C, Dilworth MR, Tunster SJ, Kimber SJ, Glazier JD, PTHrP is essential for normal morphogenetic and functional development of the murine placenta. Dev Biol. 2017 Oct 15;430(2):325-336
3	J:285119 Eaton M, Davies AH, Devine J, Zhao X, Simmons DG, Mariusdottir E, Natale DRC, Matyas JR, Bering EA, Workentine ML, Hallgrimsson B, Cross JC, Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction. PLoS One. 2020;15(1):e0226735
2	J:173620 Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B, p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth. Development. 2011 Jun;138(11):2235-47
1	J:240175 Kelleher AM, Peng W, Pru JK, Pru CA, DeMayo FJ, Spencer TE, Forkhead box a2 (FOXA2) is essential for uterine function and fertility. Proc Natl Acad Sci U S A. 2017 Feb 07;114(6):E1018-E1026
10	J:215340 Kibschull M, Colaco K, Matysiak-Zablocki E, Winterhager E, Lye SJ, Connexin31.1 (gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development. Stem Cells Dev. 2014 Nov 1;23(21):2649-60
2*	J:209833 Kim J, Frey WD, He H, Kim H, Ekram MB, Bakshi A, Faisal M, Perera BP, Ye A, Teruyama R, Peg3 mutational effects on reproduction and placenta-specific gene families. PLoS One. 2013;8(12):e83359
3	J:135979 Knox K, Baker JC, Genomic evolution of the placenta using co-option and duplication and divergence. Genome Res. 2008 May;18(5):695-705
2	J:294595 Koppes E, Shaffer B, Sadovsky E, Himes K, Barak Y, Sadovsky Y, Chaillet JR, Klf14 is an imprinted transcription factor that regulates placental growth. Placenta. 2019 Dec;88:61-67
2	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
1	J:123073 Kruger I, Vollmer M, Simmons DG, Elsasser HP, Philipsen S, Suske G, Sp1/Sp3 compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defects. Dev Dyn. 2007 Aug;236(8):2235-44
2	J:263810 Langford MB, Outhwaite JE, Hughes M, Natale DRC, Simmons DG, Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice. Sci Rep. 2018 Mar 2;8(1):3961
3	J:323371 Lee JG, Kim G, Park SG, Yon JM, Yeom J, Song HE, Cheong SA, Lim JS, Sung YH, Kim K, Yoo HJ, Hong EJ, Nam KH, Seong JK, Kim CJ, Nam SY, Baek IJ, Lipid signatures reflect the function of the murine primary placentation. Biol Reprod. 2022 Mar 19;106(3):583-596
1	J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
2	J:305960 Li F, Xu R, Lin CL, Low BE, Cai L, Li S, Ji P, Huang L, Wiles MV, Hannun YA, Obeid LM, Chen Y, Mao C, Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB J. 2020 Nov;34(11):15252-15268
2*	J:260526 Min S, Natale BV, Natale DRC, Temporal and spatial expression of glyceraldehyde 3-phosphate dehydrogenase (Gapdh) in the mouse placenta. Placenta. 2017 Sep;57:170-174
2	J:286013 Outhwaite JE, Patel J, Simmons DG, Secondary Placental Defects in Cxadr Mutant Mice. Front Physiol. 2019;10:622
1	J:185829 Park CB, DeMayo FJ, Lydon JP, Dufort D, NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Biol Reprod. 2012 Jun;86(6):194
2*	J:258221 Rakoczy J, Padmanabhan N, Krzak AM, Kieckbusch J, Cindrova-Davies T, Watson ED, Dynamic expression of TET1, TET2, and TET3 dioxygenases in mouse and human placentas throughout gestation. Placenta. 2017 Nov;59:46-56
1	J:239786 Rakoczy J, Zhang Z, Bowling FG, Dawson PA, Simmons DG, Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015 Nov;25(11):1273-6
2	J:194978 Reichmann J, Reddington JP, Best D, Read D, Ollinger R, Meehan RR, Adams IR, The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice. Hum Mol Genet. 2013 May 1;22(9):1791-806
2	J:262281 Sarkar AA, Sabatino JA, Sugrue KF, Zohn IE, Abnormal labyrinthine zone in the Hectd1-null placenta. Placenta. 2016 Feb;38:16-23
1	J:240089 Sharma N, Kubaczka C, Kaiser S, Nettersheim D, Mughal SS, Riesenberg S, Holzel M, Winterhager E, Schorle H, Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest. Development. 2016 Mar 01;143(5):787-98
13	J:122534 Simmons DG, Fortier AL, Cross JC, Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta. Dev Biol. 2007 Apr 15;304(2):567-78
1*	J:136716 Simmons DG, Natale DR, Begay V, Hughes M, Leutz A, Cross JC, Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development. 2008 Jun;135(12):2083-91
3	J:60138 Sol-Church K, Frenck J, Mason RW, Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placenta. Biochem Biophys Res Commun. 2000 Jan 27;267(3):791-5
2	J:315981 Torregrosa-Carrion R, Pineiro-Sabaris R, Siguero-Alvarez M, Grego-Bessa J, Luna-Zurita L, Fernandes VS, MacGrogan D, Stainier DYR, de la Pompa JL, Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Sci Adv. 2021 Nov 12;7(46):eabj5445
1	J:228795 Tunster SJ, Creeth HD, John RM, The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Dev Biol. 2016 Jan 1;409(1):251-60
1	J:236398 Tunster SJ, McNamara GI, Creeth HD, John RM, Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. Dev Biol. 2016 Oct 1;418(1):55-65
3	J:267708 Tunster SJ, Van de Pette M, Creeth HDJ, Lefebvre L, John RM, Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Dis Model Mech. 2018 Nov 16;11(11):dmm035832
2*	J:177542 Tunster SJ, Van de Pette M, John RM, Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Dis Model Mech. 2011 Nov;4(6):814-21
4	J:290416 Vrooman LA, Rhon-Calderon EA, Chao OY, Nguyen DK, Narapareddy L, Dahiya AK, Putt ME, Schultz RM, Bartolomei MS, Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse. Development. 2020 May 29;147(11):dev186551
2	J:252754 Woods L, Perez-Garcia V, Kieckbusch J, Wang X, DeMayo F, Colucci F, Hemberger M, Decidualisation and placentation defects are a major cause of age-related reproductive decline. Nat Commun. 2017 Sep 05;8(1):352
3	J:235000 Wu HH, Choi S, Levitt P, Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse. Placenta. 2016 Jun;42:74-83