Gene Expression Literature Summary

• Symbol: Pard6b
• Name: par-6 family cell polarity regulator beta
• ID: MGI:2135605

36 matching records from 36 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2	E2.5	E3	E3.5	E4	E4.5	E5.5	E6.5	E8.5	E9.5	E10.5	E11	E11.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)			2		1	4	5	2	2	1	2		1	6	2	2	1	1	2	2	6
In situ RNA (section)																1
Immunohistochemistry (whole mount)		1	1					1									1		1		2
Western blot												1		1					1		1
RT-PCR	1		1	1																	1
cDNA clones																					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pard6b  par-6 family cell polarity regulator beta
Results	Reference
1	J:331266 Abou Nader N, Menard A, Levasseur A, St-Jean G, Boerboom D, Zamberlam G, Boyer A, Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate. Int J Mol Sci. 2022 Nov 5;23(21)
2	J:336187 Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O, Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 Jul;499:59-74
3	J:116100 Chen L, Liao G, Yang L, Campbell K, Nakafuku M, Kuan CY, Zheng Y, Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16520-5
3*	J:119954 Cui XS, Li XY, Shen XH, Bae YJ, Kang JJ, Kim NH, Transcription profile in mouse four-cell, morula, and blastocyst: Genes implicated in compaction and blastocoel formation. Mol Reprod Dev. 2007 Feb;74(2):133-43
2	J:201606 Ezan J, Lasvaux L, Gezer A, Novakovic A, May-Simera H, Belotti E, Lhoumeau AC, Birnbaumer L, Beer-Hammer S, Borg JP, Le Bivic A, Nurnberg B, Sans N, Montcouquiol M, Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol. 2013 Sep;15(9):1107-15
2*	J:297709 Fan R, Kim YS, Wu J, Chen R, Zeuschner D, Mildner K, Adachi K, Wu G, Galatidou S, Li J, Scholer HR, Leidel SA, Bedzhov I, Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. Nat Commun. 2020 Oct 30;11(1):5499
1	J:275506 Frum T, Ralston A, Visualizing HIPPO Signaling Components in Mouse Early Embryonic Development. Methods Mol Biol. 2019;1893:335-352
3*	J:245763 Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK, Afadin orients cell division to position the tubule lumen in developing renal tubules. Development. 2017 Oct 01;144(19):3511-3520
1	J:161201 Gao N, Kaestner KH, Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev. 2010 Jun 15;24(12):1295-305
1	J:271615 Haag N, Schuler S, Nietzsche S, Hubner CA, Strenzke N, Qualmann B, Kessels MM, The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep. 2018 Aug 28;24(9):2418-2431.e6
2	J:140256 Hartleben B, Schweizer H, Lubben P, Bartram MP, Moller CC, Herr R, Wei C, Neumann-Haefelin E, Schermer B, Zentgraf H, Kerjaschki D, Reiser J, Walz G, Benzing T, Huber TB, Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008 Aug 22;283(34):23033-8
1*	J:337132 Hiremath C, Gao L, Geshow K, Patterson Q, Barlow H, Cleaver O, Marciano DK, Rap1 regulates lumen continuity via Afadin in renal epithelia. Dev Biol. 2023 Jun 3;501:20-27
1	J:146415 Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T, PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006 Apr;133(7):1389-98
1	J:122204 Imai F, Hirai S, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T, Ohno S, Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development. 2006 May;133(9):1735-44
1	J:253478 Jiang T, Kindt K, Wu DK, Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells. Elife. 2017 Mar 7;6:e23661
2	J:157396 Kesavan G, Sand FW, Greiner TU, Johansson JK, Kobberup S, Wu X, Brakebusch C, Semb H, Cdc42-mediated tubulogenesis controls cell specification. Cell. 2009 Nov 13;139(4):791-801
3	J:306396 Kim YS, Fan R, Kremer L, Kuempel-Rink N, Mildner K, Zeuschner D, Hekking L, Stehling M, Bedzhov I, Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning. Sci Adv. 2021 Mar;7(11)
3	J:327957 Kim YS, Fan R, Lith SC, Dicke AK, Drexler HCA, Kremer L, Kuempel-Rink N, Hekking L, Stehling M, Bedzhov I, Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition. Dev Cell. 2022 Aug 22;57(16):1937-1956.e8
1	J:306060 Kindt KS, Akturk A, Jarysta A, Day M, Beirl A, Flonard M, Tarchini B, EMX2-GPR156-Galphai reverses hair cell orientation in mechanosensory epithelia. Nat Commun. 2021 May 17;12(1):2861
1	J:239148 Korotkevich E, Niwayama R, Courtois A, Friese S, Berger N, Buchholz F, Hiiragi T, The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo. Dev Cell. 2017 Feb 06;40(3):235-247.e7
2	J:273200 Landin Malt A, Dailey Z, Holbrook-Rasmussen J, Zheng Y, Hogan A, Du Q, Lu X, Par3 is essential for the establishment of planar cell polarity of inner ear hair cells. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4999-5008
1	J:230827 Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch-Grau M, Aghaie A, Perfettini I, Dupont T, Avan P, El-Amraoui A, Petit C, Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. J Cell Biol. 2016 Jan 18;212(2):231-44
1	J:310879 Lesko AC, Keller R, Chen P, Sutherland A, Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure. Dev Biol. 2021 Oct;478:59-75
1	J:296989 Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N, Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature. 2020 Sep;585(7825):404-409
1	J:316167 Liu K, Lin Q, Wei Y, He R, Shao X, Ding Z, Zhang J, Zhu M, Weinstein LS, Hong Y, Li H, Li H, Galphas regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neurosci Lett. 2015 Jun 15;597:97-103
1	J:297063 Najarro EH, Huang J, Jacobo A, Quiruz LA, Grillet N, Cheng AG, Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea. Development. 2020 Oct 5;147(19):dev191981
2*	J:196288 Nechiporuk T, Klezovitch O, Nguyen L, Vasioukhin V, Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol. 2013 May 15;377(2):375-84
2	J:334840 Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D, Trappmann B, Ranga A, Bedzhov I, Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage. Cell Rep. 2023 Mar 28;42(4):112313
4	J:321506 Royer C, Sandham E, Slee E, Schneider F, Lagerholm CB, Godwin J, Veits N, Hathrell H, Zhou F, Leonavicius K, Garratt J, Narendra T, Vincent A, Jones C, Child T, Coward K, Graham C, Fritzsche M, Lu X, Srinivas S, ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis. Nat Commun. 2022 Feb 17;13(1):941
1	J:311928 Schmid MT, Weinandy F, Wilsch-Brauninger M, Huttner WB, Cappello S, Gotz M, The role of alpha-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration. Front Cell Neurosci. 2014;8:215
1	J:183948 Tao H, Inoue K, Kiyonari H, Bassuk AG, Axelrod JD, Sasaki H, Aizawa S, Ueno N, Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol. 2012 Apr 15;364(2):138-48
2	J:105811 Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C, Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 1;20(5):571-85
1	J:195126 Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM 3rd, Reichardt LF, Marciano DK, De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity. Development. 2013 Apr;140(8):1774-84
2*	J:240523 Yang Z, Zimmerman SE, Tsunezumi J, Braitsch C, Trent C, Bryant DM, Cleaver O, Gonzalez-Manchon C, Marciano DK, Role of CD34 family members in lumen formation in the developing kidney. Dev Biol. 2016 Oct 01;418(1):66-74
1	J:167938 Yi JJ, Barnes AP, Hand R, Polleux F, Ehlers MD, TGF-beta signaling specifies axons during brain development. Cell. 2010 Jul 9;142(1):144-57
1	J:306543 Yu Z, Zeng J, Wang J, Cui Y, Song X, Zhang Y, Cheng X, Hou N, Teng Y, Lan Y, Chen Y, Yang X, Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability. Cardiovasc Res. 2021 Jan 21;117(2):533-546