Gene Expression Literature Summary

• Symbol: Opa1
• Name: OPA1, mitochondrial dynamin like GTPase
• ID: MGI:1921393

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E3.5	E9.5	E10.5	E11.5	E14.5	E15.5	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)						1	1	1	1			1
In situ RNA (section)							1
Immunohistochemistry (whole mount)		1
In situ RNA (whole mount)			1
Western blot		1		1	1					2	1	6
RT-PCR	1	1				2		1		1		2
cDNA clones				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Opa1  OPA1, mitochondrial dynamin like GTPase   (Synonyms: 1200011N24Rik, lilr3, optic atrophy 1)
Results	Reference
5*	J:92284 Aijaz S, Erskine L, Jeffery G, Bhattacharya SS, Votruba M, Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer. Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1667-73
1	J:271287 Fakruddin M, Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K, Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease. Cell Rep. 2018 Jan 9;22(2):482-496
1	J:235368 Gomez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acin-Perez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jimenez-Alcazar M, Segales J, Lopez-Maderuelo D, Ornes B, Jimenez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Munoz-Canoves P, Redondo JM, The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016 May 10;23(5):881-92
1	J:158142 Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K, Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol. 2009 Aug;11(8):958-66
1	J:337002 Kenny TC, Khan A, Son Y, Yue L, Heissel S, Sharma A, Pasolli HA, Liu Y, Gamazon ER, Alwaseem H, Hite RK, Birsoy K, Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals. Cell Metab. 2023 Jun 6;35(6):1057-1071.e12
1	J:267504 Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA, Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 Oct 17;13(1):56
4*	J:329326 Marta C, Dawid W, Silvestre S, Pawel G, Salvatore P, Modlinski JA, Pasqualino L, Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos. Sci Rep. 2022 Sep 27;12(1):16152
1	J:237617 Menendez-Montes I, Escobar B, Palacios B, Gomez MJ, Izquierdo-Garcia JL, Flores L, Jimenez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S, Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Dev Cell. 2016 Dec 19;39(6):724-739
1	J:307395 Mirra S, Garcia-Arroyo R, B Domenech E, Gavalda-Navarro A, Herrera-Ubeda C, Oliva C, Garcia-Fernandez J, Artuch R, Villarroya F, Marfany G, CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina. Neurobiol Dis. 2021 Aug;156:105405
2	J:162916 Moore BA, Gonzalez Aviles GD, Larkins CE, Hillman MJ, Caspary T, Mitochondrial retention of Opa1 is required for mouse embryogenesis. Mamm Genome. 2010 Aug;21(7-8):350-60
1*	J:226977 Moriya M, Inoue S, Miyagawa-Tomita S, Nakashima Y, Oba D, Niihori T, Hashi M, Ohnishi H, Kure S, Matsubara Y, Aoki Y, Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype. Hum Mol Genet. 2015 Dec 20;24(25):7349-60
2	J:316416 Perico L, Morigi M, Pezzotta A, Corna D, Brizi V, Conti S, Zanchi C, Sangalli F, Trionfini P, Butto S, Xinaris C, Tomasoni S, Zoja C, Remuzzi G, Benigni A, Imberti B, Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis. Sci Rep. 2021 Dec 8;11(1):23580
1	J:151566 Rochais F, Dandonneau M, Mesbah K, Jarry T, Mattei MG, Kelly RG, Hes1 is expressed in the second heart field and is required for outflow tract development. PLoS One. 2009;4(7):e6267
2	J:331835 Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN, Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice. Biol Reprod. 2022 Jun 13;106(6):1292-1311
1*	J:249661 Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI, CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017 Mar 06;216(3):675-693
3	J:333326 Suh J, Kim NK, Shim W, Lee SH, Kim HJ, Moon E, Sesaki H, Jang JH, Kim JE, Lee YS, Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis. Cell Metab. 2023 Feb 7;35(2):345-360.e7
1	J:338452 Wang D, Li H, Chandel NS, Dou Y, Yi R, MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters. Nat Commun. 2023 Jul 21;14(1):4404