Gene Expression Literature Summary

• Symbol: Nphs1
• Name: nephrosis 1, nephrin
• ID: MGI:1859637

71 matching records from 71 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)		1	1	2	6	4	1	7	10	2	34
In situ RNA (section)	1	2	2	2	4	3		1	1		6
Immunohistochemistry (whole mount)					1						1
Northern blot											1
Western blot		1			1		1		1		4
RT-PCR		1	2		3				3		9
cDNA clones			1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nphs1  nephrosis 1, nephrin   (Synonyms: nephrin)
Results	Reference
1	J:332930 Anderson MJ, Misaghian S, Sharma N, Perantoni AO, Lewandoski M, Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis. Differentiation. 2022 Dec 6;130:7-15
1	J:239479 Arora H, Boulberdaa M, Qureshi R, Bitirim V, Messadeq N, Dolle P, Nebigil CG, Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development. FASEB J. 2016 Aug;30(8):2733-40
1	J:324218 Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Muller-Deile J, Schluter H, Puelles VG, Bergmann C, Huber TB, Grahammer F, Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy. J Clin Invest. 2022 May 2;132(9):e147253
1	J:314570 Babayeva S, Rocque B, Aoudjit L, Zilber Y, Li J, Baldwin C, Kawachi H, Takano T, Torban E, Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes. J Biol Chem. 2013 Aug 16;288(33):24035-48
1*	J:168261 Babayeva S, Zilber Y, Torban E, Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am J Physiol Renal Physiol. 2011 Feb;300(2):F549-60
2	J:283488 Bartlett CS, Scott RP, Carota IA, Wnuk ML, Kanwar YS, Miner JH, Quaggin SE, Glomerular mesangial cell recruitment and function require the co-receptor neuropilin-1. Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1232-F1242
1	J:186872 Bonegio RG, Beck LH, Kahlon RK, Lu W, Salant DJ, The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int. 2011 May;79(10):1099-112
1*	J:177885 Brunskill EW, Georgas K, Rumballe B, Little MH, Potter SS, Defining the molecular character of the developing and adult kidney podocyte. PLoS One. 2011;6(9):e24640
1	J:239251 Brzoska HL, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA, Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016 Dec;90(6):1274-1284
1	J:93150 Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW, Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. Gene Expr Patterns. 2004 Oct;4(6):611-9
1*	J:147670 Done SC, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, Tryggvason K, Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int. 2008 Mar;73(6):697-704
1	J:70294 Doyonnas R, Kershaw DB, Duhme C, Merkens H, Chelliah S, Graf T, McNagny KM, Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. J Exp Med. 2001 Jul 2;194(1):13-27
1	J:196018 Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W, Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep. 2012 Jul 26;2(1):52-61
1	J:240644 Fan X, Yang H, Kumar S, Tumelty KE, Pisarek-Horowitz A, Rasouly HM, Sharma R, Chan S, Tyminski E, Shamashkin M, Belghasem M, Henderson JM, Coyle AJ, Salant DJ, Berasi SP, Lu W, SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. JCI Insight. 2016 Nov 17;1(19):e86934
1*	J:336175 Fuchs MAA, Schrankl J, Leupold C, Wagner C, Kurtz A, Broeker KA, Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F295-F307
2	J:243840 Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B, Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511
5	J:241326 Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Brauniger R, Rinschen MM, Volker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB, A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight. 2016 Jun 16;1(9)
2	J:333283 Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH, Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Kidney Int. 2022 Jul;102(1):108-120
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:293086 Guo B, Lyu Q, Slivano OJ, Dirkx R, Christie CK, Czyzyk J, Hezel AF, Gharavi AG, Small EM, Miano JM, Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function. J Am Soc Nephrol. 2018 Feb;29(2):416-422
1	J:189818 Haege S, Einer C, Thiele S, Mueller W, Nietzsche S, Lupp A, Mackay F, Schulz S, Stumm R, CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney. PLoS One. 2012;7(8):e42814
3	J:140256 Hartleben B, Schweizer H, Lubben P, Bartram MP, Moller CC, Herr R, Wei C, Neumann-Haefelin E, Schermer B, Zentgraf H, Kerjaschki D, Reiser J, Walz G, Benzing T, Huber TB, Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008 Aug 22;283(34):23033-8
1	J:190169 Hartleben B, Widmeier E, Wanner N, Schmidts M, Kim ST, Schneider L, Mayer B, Kerjaschki D, Miner JH, Walz G, Huber TB, Role of the polarity protein Scribble for podocyte differentiation and maintenance. PLoS One. 2012;7(5):e36705
2	J:171732 Heikkila E, Ristola M, Havana M, Jones N, Holthofer H, Lehtonen S, Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin. Biochem J. 2011 May 1;435(3):619-28
2	J:194051 Heliot C, Desgrange A, Buisson I, Prunskaite-Hyyrylainen R, Shan J, Vainio S, Umbhauer M, Cereghini S, HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development. 2013 Feb;140(4):873-85
2	J:280081 Hou G, Wu V, Singh G, Holzman LB, Tsui CC, Ret is critical for podocyte survival following glomerular injury in vivo. Am J Physiol Renal Physiol. 2015 Apr 1;308(7):F774-83
2*	J:198192 Huang J, Arsenault M, Kann M, Lopez-Mendez C, Saleh M, Wadowska D, Taglienti M, Ho J, Miao Y, Sims D, Spears J, Lopez A, Wright G, Hartwig S, The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo. Dev Dyn. 2013 Jun;242(6):790-9
1	J:272294 Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, Sakamoto K, Tsurutani Y, Ide S, Ide K, Kawamura H, Kobayashi K, Tokuyama H, Tryggvason K, Betsholtz C, Yokote K, A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation. Sci Rep. 2016 May 16;6:25955
1	J:181998 Kakani S, Yardeni T, Poling J, Ciccone C, Niethamer T, Klootwijk ED, Manoli I, Darvish D, Hoogstraten-Miller S, Zerfas P, Tian E, Ten Hagen KG, Kopp JB, Gahl WA, Huizing M, The Gne M712T Mouse as a Model for Human Glomerulopathy. Am J Pathol. 2012 Apr;180(4):1431-40
2	J:295408 Kanai M, Jeon H, Ojima M, Nishino T, Usui T, Yadav MK, Kulathunga K, Morito N, Takahashi S, Hamada M, Phenotypic analysis of mice carrying human-type MAFB p.Leu239Pro mutation. Biochem Biophys Res Commun. 2020 Mar 5;523(2):452-457
1	J:130822 Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH Jr, Kalluri R, Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008 Jan 15;313(2):584-93
1	J:220461 Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA, WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015 Apr 1;142(7):1254-66
2	J:321519 Kelam N, Racetin A, Katsuyama Y, Vukojevic K, Kostic S, Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice. Int J Mol Sci. 2022 Feb 11;23(4)
1	J:83911 Kos CH, Le TC, Sinha S, Henderson JM, Kim SH, Sugimoto H, Kalluri R, Gerszten RE, Pollak MR, Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest. 2003 Jun;111(11):1683-90
2	J:321428 Kruber P, Angay O, Winkler A, Bosl MR, Kneitz S, Heinze KG, Gessler M, Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation. Int J Cancer. 2019 Mar 15;144(6):1391-1400
1	J:333146 Kumar S, Fan X, Rasouly HM, Sharma R, Salant DJ, Lu W, ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis. JCI Insight. 2023 Jan 10;8(1)
4*	J:316994 Lefebvre J, Clarkson M, Massa F, Bradford ST, Charlet A, Buske F, Lacas-Gervais S, Schulz H, Gimpel C, Hata Y, Schaefer F, Schedl A, Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015 Aug;88(2):321-31
2	J:337772 Liang X, Aranyi T, Zhou J, Guan Y, Hu H, Liu H, Susztak K, Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment. J Am Soc Nephrol. 2023 Apr 1;34(4):572-589
2	J:171425 Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM 3rd, Hofmann I, Mostov KE, Reichardt LF, p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May;138(10):2099-109
1	J:170932 Marshall CB, Krofft RD, Blonski MJ, Kowalewska J, Logar CM, Pippin JW, Kim F, Feil R, Alpers CE, Shankland SJ, Role of smooth muscle protein SM22{alpha} in glomerular epithelial cell injury. Am J Physiol Renal Physiol. 2011 Apr;300(4):F1026-42
1	J:313623 Moktefi A, Zhang SY, Vachin P, Ory V, Henique C, Audard V, Rucker-Martin C, Gouadon E, Eccles M, Schedl A, Heidet L, Ollero M, Sahali D, Pawlak A, Repression of CMIP transcription by WT1 is relevant to podocyte health. Kidney Int. 2016 Dec;90(6):1298-1311
1	J:229413 Moon S, Um SJ, Kim EJ, Role of Asxl1 in kidney podocyte development via its interaction with Wtip. Biochem Biophys Res Commun. 2015 Oct 23;466(3):560-6
1	J:275533 Murakami Y, Naganuma H, Tanigawa S, Fujimori T, Eto M, Nishinakamura R, Reconstitution of the embryonic kidney identifies a donor cell contribution to the renal vasculature upon transplantation. Sci Rep. 2019 Feb 4;9(1):1172
2*	J:302552 Naganuma H, Miike K, Ohmori T, Tanigawa S, Ichikawa T, Yamane M, Eto M, Niwa H, Kobayashi A, Nishinakamura R, Molecular detection of maturation stages in the developing kidney. Dev Biol. 2021 Feb;470:62-73
2	J:288722 Nilsson D, Heglind M, Arani Z, Enerback S, Foxc2 is essential for podocyte function. Physiol Rep. 2019 May;7(9):e14083
6*	J:158304 Nishida K, Hoshino M, Kawaguchi Y, Murakami F, Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system. J Biol Chem. 2010 Jan 1;285(1):373-80
1	J:171288 Nishida K, Nakayama K, Yoshimura S, Murakami F, Role of Neph2 in pontine nuclei formation in the developing hindbrain. Mol Cell Neurosci. 2011 Mar;46(3):662-70
1	J:142530 Pitera JE, Scambler PJ, Woolf AS, Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Hum Mol Genet. 2008 Dec 15;17(24):3953-64
1	J:255143 Rasouly HM, Kumar S, Chan S, Pisarek-Horowitz A, Sharma R, Xi QJ, Nishizaki Y, Higashi Y, Salant DJ, Maas RL, Lu W, Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease. Kidney Int. 2016 Dec;90(6):1262-1273
1	J:195266 Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H, Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
1	J:217530 Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M, iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910
1	J:293073 Rocque BL, Babayeva S, Li J, Leung V, Nezvitsky L, Cybulsky AV, Gros P, Torban E, Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury. J Am Soc Nephrol. 2015 Mar;26(3):576-86
1	J:333727 Rogg M, Maier JI, Dotzauer R, Artelt N, Kretz O, Helmstadter M, Abed A, Sammarco A, Sigle A, Sellung D, Dinse P, Reiche K, Yasuda-Yamahara M, Biniossek ML, Walz G, Werner M, Endlich N, Schilling O, Huber TB, Schell C, SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance. J Am Soc Nephrol. 2021 Mar;32(3):563-579
2*	J:113418 Ross MD, Martinka S, Mukherjee A, Sedor JR, Vinson C, Bruggeman LA, Math6 expression during kidney development and altered expression in a mouse model of glomerulosclerosis. Dev Dyn. 2006 Nov;235(11):3102-9
1*	J:182970 Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvonen ME, Perala N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, de Angelis MH, Frilander MJ, Savilahti H, Sariola H, SainioK, Lehtonen S, Taipale J, Salminen M, Lappalainen P, Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci. 2011 Apr 15;124(Pt 8):1245-55
4	J:78764 Sadl V, Jin F, Yu J, Cui S, Holmyard D, Quaggin S, Barsh G, Cordes S, The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells. Dev Biol. 2002 Sep 1;249(1):16-29
1	J:208128 Sarin S, Boivin F, Li A, Lim J, Svajger B, Rosenblum ND, Bridgewater D, beta-Catenin Overexpression in the Metanephric Mesenchyme Leads to Renal Dysplasia Genesis via Cell-Autonomous and Non-Cell-Autonomous Mechanisms. Am J Pathol. 2014 May;184(5):1395-410
1	J:233807 Schell C, Kretz O, Bregenzer A, Rogg M, Helmstadter M, Lisewski U, Gotthardt M, Tharaux PL, Huber TB, Grahammer F, Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response. PLoS One. 2015;10(6):e0129424
1	J:242275 Schell C, Rogg M, Suhm M, Helmstadter M, Sellung D, Yasuda-Yamahara M, Kretz O, Kuttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB, The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. Proc Natl Acad Sci U S A. 2017 Jun 06;114(23):E4621-E4630
2*	J:150083 Sohn RL, Huang P, Kawahara G, Mitchell M, Guyon J, Kalluri R, Kunkel LM, Gussoni E, A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9274-9
1	J:232342 Stewart K, Gaitan Y, Shafer ME, Aoudjit L, Hu D, Sharma R, Tremblay M, Ishii H, Marcotte M, Stanga D, Tang YC, Boualia SK, Nguyen AH, Takano T, Lamarche-Vane N, Vidal S, Bouchard M, A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects. PLoS Genet. 2016 Feb;12(2):e1005785
3	J:272614 Suzuki A, Minamide R, Iwata J, WNT/beta-catenin signaling plays a crucial role in myoblast fusion through regulation of nephrin expression during development. Development. 2018 Nov 27;145(23):dev168351
1	J:164624 Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni PA, Nagasawa Y, Hamano T, Matsui I, Kawada N, Imai E, Nagasawa T, Rakugi H, Isaka Y, The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol. 2009 Aug;20(8):1714-23
1	J:240685 Takara K, Maruo N, Oka K, Kaji C, Hatakeyama Y, Sawa N, Kato Y, Yamashita J, Kojima H, Sawa Y, Morphological study of tooth development in podoplanin-deficient mice. PLoS One. 2017;12(2):e0171912
1*	J:106710 Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C, Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
2	J:320196 Tanigawa S, Tanaka E, Miike K, Ohmori T, Inoue D, Cai CL, Taguchi A, Kobayashi A, Nishinakamura R, Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma. Nat Commun. 2022 Feb 1;13(1):611
1	J:309992 Vasilopoulou E, Kolatsi-Joannou M, Lindenmeyer MT, White KE, Robson MG, Cohen CD, Sebire NJ, Riley PR, Winyard PJ, Long DA, Loss of endogenous thymosin beta4 accelerates glomerular disease. Kidney Int. 2016 Nov;90(5):1056-1070
1	J:290543 Vidal VP, Jian-Motamedi F, Rekima S, Gregoire EP, Szenker-Ravi E, Leushacke M, Reversade B, Chaboissier MC, Schedl A, R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors. Elife. 2020 May 1;9:e53895
10	J:171496 Wagner N, Morrison H, Pagnotta S, Michiels JF, Schwab Y, Tryggvason K, Schedl A, Wagner KD, The podocyte protein nephrin is required for cardiac vessel formation. Hum Mol Genet. 2011 Jun 1;20(11):2182-94
3*	J:296647 Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB, DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. J Am Soc Nephrol. 2019 Jan;30(1):63-78
3*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76