Gene Expression Literature Summary

• Symbol: Aire
• Name: autoimmune regulator
• ID: MGI:1338803

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E6.5	E7	E7.5	E8	E8.5	E9.5	E10.5	E11	E12.5	E13.5	E14.5	E15.5	E16.5	E17	E17.5	E18.5	E19	P
Immunohistochemistry (section)	1																		1	2	2		4	3		17
In situ RNA (section)																		1	4		1					2
Immunohistochemistry (whole mount)	1		1				1																			1
In situ RNA (whole mount)														1	2					1
In situ reporter (knock in)																		1			1					1
Northern blot																										2
Western blot																										1
RT-PCR		1	1	1	1	1	2	1	1	1	1	1	1	1			3	3	1	2	1		3	2	1	11
cDNA clones										1						1						1				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Aire  autoimmune regulator
Results	Reference
2	J:236470 Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T, Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J Exp Med. 2016 Jul 25;213(8):1441-58
1	J:97344 Akiyama T, Maeda S, Yamane S, Ogino K, Kasai M, Kajiura F, Matsumoto M, Inoue J, Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science. 2005 Apr 8;308(5719):248-51
4	J:139649 Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J, The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 2008 Sep;29(3):423-37
4*	J:320323 Bin G, Jiarong Z, Shihao W, Xiuli S, Cheng X, Liangbiao C, Ming Z, Aire promotes the self-renewal of embryonic stem cells through Lin28. Stem Cells Dev. 2012 Oct 10;21(15):2878-90
6*	J:53196 Blechschmidt K, Schweiger M, Wertz K, Poulson R, Christensen HM , Rosenthal A , Lehrach H , Yaspo ML, The mouse Aire gene: comparative genomic sequencing, gene organization, and expression. Genome Res. 1999 Feb;9(2):158-66
4	J:186289 Brahmaraju M, Bhagya KP, Titus S, Sebastian A, Devi AN, Laloraya M, Kumar PG, AIRE1A might be involved in cyclin B2 degradation in testicular lysates. Biochem Cell Biol. 2011 Aug;89(4):411-22
1*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:153593 Dooley J, Erickson M, Farr AG, Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium. J Immunol. 2009 Oct 15;183(8):5042-9
1	J:318898 Fujimori S, Ohigashi I, Abe H, Matsushita Y, Katagiri T, Taketo MM, Takahama Y, Takada S, Fine-tuning of beta-catenin in mouse thymic epithelial cells is required for postnatal T-cell development. Elife. 2022 Jan 19;11:e69088
1	J:322001 Gao H, Cao M, Deng K, Yang Y, Song J, Ni M, Xie C, Fan W, Ou C, Huang D, Lin L, Liu L, Li Y, Sun H, Cheng X, Wu J, Xia C, Deng X, Mou L, Chen P, The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis. Front Immunol. 2022;13:805451
1*	J:80501 Gitton Y, Dahmane N, Baik S, Ruiz I Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1	J:242967 Gu B, Lambert JP, Cockburn K, Gingras AC, Rossant J, AIRE is a critical spindle-associated protein in embryonic stem cells. Elife. 2017 Jul 25;6:e28131
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:248683 Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R, Meis1 is required for the maintenance of postnatal thymic epithelial cells. PLoS One. 2014;9(3):e89885
5*	J:124288 Kont V, Laan M, Kisand K, Merits A, Scott HS, Peterson P, Modulation of Aire regulates the expression of tissue-restricted antigens. Mol Immunol. 2008 Jan;45(1):25-33
4*	J:157503 Laan M, Kisand K, Kont V, Moll K, Tserel L, Scott HS, Peterson P, Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol. 2009 Dec 15;183(12):7682-91
1*	J:278361 Larsen BM, Cowan JE, Wang Y, Tanaka Y, Zhao Y, Voisin B, Constantinides MG, Nagao K, Belkaid Y, Awasthi P, Takahama Y, Bhandoola A, Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells. J Immunol. 2019 Aug 1;203(3):686-695
3	J:290414 Li J, Gordon J, Chen ELY, Xiao S, Wu L, Zuniga-Pflucker JC, Manley NR, NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development. Development. 2020 Jun 22;147(12):dev178988
1	J:194053 Liu B, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ, Zhang XR, Botchkarev VA, Zhang Y, Xu GL, Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
1	J:291487 Liu D, Kousa AI, O'Neill KE, Rouse P, Popis M, Farley AM, Tomlinson SR, Ulyanchenko S, Guillemot F, Seymour PA, Jorgensen MC, Serup P, Koch U, Radtke F, Blackburn CC, Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development. Development. 2020 Jun 22;147(12):dev178582
1	J:342615 Malin J, Martinez-Ruiz GU, Zhao Y, Shissler SC, Cowan JE, Ding Y, Morales-Sanchez A, Ishikawa M, Lavaert M, Das A, Butcher D, Warner AC, Kallarakal M, Chen J, Kedei N, Kelly M, Brinster LR, Allman D, Bhandoola A, Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development. Sci Adv. 2023 Nov 17;9(46):eadg8126
2	J:309668 Montero-Herradon S, Garcia-Ceca J, Zapata AG, Altered Maturation of Medullary TEC in EphB-Deficient Thymi Is Recovered by RANK Signaling Stimulation. Front Immunol. 2018;9:1020
1	J:333187 Montero-Herradon S, Zapata AG, Delayed maturation of thymic epithelium in mice with specific deletion of beta-catenin gene in FoxN1 positive cells. Histochem Cell Biol. 2021 Oct;156(4):315-332
3	J:293206 Munoz JJ, Tobajas E, Juara S, Montero S, Zapata AG, FoxN1 mediates thymic cortex-medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis. Histochem Cell Biol. 2019 Dec;152(6):397-413
1*	J:274110 Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M, Fgf21 regulates T-cell development in the neonatal and juvenile thymus. Sci Rep. 2017 Mar 23;7(1):330
7*	J:160217 Nishikawa Y, Hirota F, Yano M, Kitajima H, Miyazaki J, Kawamoto H, Mouri Y, Matsumoto M, Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med. 2010 May 10;207(5):963-71
1	J:222872 Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu-Takanashi R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H, The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gammadeltaT cells. EMBO Rep. 2015 May;16(5):638-53
1*	J:177992 Nowell CS, Bredenkamp N, Tetelin S, Jin X, Tischner C, Vaidya H, Sheridan JM, Stenhouse FH, Heussen R, Smith AJ, Blackburn CC, Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 2011 Nov;7(11):e1002348
1	J:214094 Reeh KA, Cardenas KT, Bain VE, Liu Z, Laurent M, Manley NR, Richie ER, Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014 Aug;141(15):2950-8
7*	J:80502 Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A, Human chromosome 21 gene expression atlas in the mouse. Nature. 2002 Dec 5;420(6915):582-6
1*	J:187054 Roberts NA, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger JM, Simon AK, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ,Anderson G, Rank signaling links the development of invariant gammadelta T cell progenitors and Aire(+) medullary epithelium. Immunity. 2012 Mar 23;36(3):427-37
1	J:157679 Saade M, Irla M, Yammine M, Boulanger N, Victorero G, Vincentelli R, Penninger JM, Hollander GA, Chauvet S, Nguyen C, Spatial (Tbata) expression in mature medullary thymic epithelial cells. Eur J Immunol. 2010 Feb;40(2):530-8
1*	J:147173 Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y, Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Blood. 2009 Mar 26;113(13):2976-87
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
4	J:141379 Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Mouri Y, Matsumoto M, Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med. 2008 Nov 24;205(12):2827-38
9*	J:63747 Zuklys S, Balciunaite G, Agarwal A, Fasler-Kan E, Palmer E, Hollander GA, Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J Immunol. 2000 Aug 15;165(4):1976-83