Gene Expression Literature Summary

• Symbol: Smn1
• Name: survival motor neuron 1
• ID: MGI:109257

20 matching records from 20 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E7	E7.5	E8.5	E9.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E16	E17	E18	E18.5	E19	E	P
Immunohistochemistry (section)												1				2				1					1			6
In situ RNA (section)												1			1	1			1	1		1		1				2
Immunohistochemistry (whole mount)	1	2		1	1	1	1		1		1													1				2
Northern blot									1				1								1		1					3
Western blot		1			1	1	1									1	1	1	2	1		1		3	1	2	1	8
RT-PCR			1	1	1	1	1	1		1		1				1				2								5
cDNA clones										1				1										1				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Smn1  survival motor neuron 1   (Synonyms: SMN)
Results	Reference
2*	J:161744 Baumer D, Lee S, Nicholson G, Davies JL, Parkinson NJ, Murray LM, Gillingwater TH, Ansorge O, Davies KE, Talbot K, Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. PLoS Genet. 2009 Dec;5(12):e1000773
5*	J:45098 Bergin A, Kim G, Price DL, Sisodia SS, Lee MK, Rabin BA, Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron. (vol. 213(1-2):227). Gene. 1997 Dec 19;204(1-2):47-53
2	J:319558 Bizen N, Bepari AK, Zhou L, Abe M, Sakimura K, Ono K, Takebayashi H, Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ. 2022;
5*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:110584 Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L, Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly. J Biol Chem. 2006 Mar 24;281(12):8126-34
12*	J:331510 Chang WF, Lin TY, Peng M, Chang CC, Xu J, Hsieh-Li HM, Liu JL, Sung LY, Survival Motor Neuron Enhances Pluripotent Gene Expression and Facilitates Cell Reprogramming. Stem Cells Dev. 2022 Nov;31(21-22):696-705
7*	J:39673 DiDonato CJ, Chen XN, Noya D, Korenberg JR, Nadeau JH, Simard LR, Cloning, characterization, and copy number of the murine survival motor neuron gene: homolog of the spinal muscular atrophy-determining gene. Genome Res. 1997 Apr;7(4):339-52
3	J:222448 Dombert B, Sivadasan R, Simon CM, Jablonka S, Sendtner M, Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons. PLoS One. 2014;9(10):e110846
3*	J:106808 Gabanella F, Carissimi C, Usiello A, Pellizzoni L, The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation. Hum Mol Genet. 2005 Dec 1;14(23):3629-42
6	J:279182 Genabai NK, Kannan A, Ahmad S, Jiang X, Bhatia K, Gangwani L, Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy. Sci Rep. 2017 Aug 15;7(1):8295
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:282329 Hildebrandt MR, Wang Y, Li L, Yasmin L, Glubrecht DD, Godbout R, Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout. Dev Biol. 2019 Nov 15;455(2):420-433
4	J:67781 Jablonka S, Bandilla M, Wiese S, Buhler D, Wirth B, Sendtner M, Fischer U, Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy. Hum Mol Genet. 2001 Mar 1;10(5):497-505
4*	J:60591 Jablonka S, Schrank B, Kralewski M, Rossoll W, Sendtner M, Reduced survival motor neuron (Smn) gene dose in mice leads to motor neuron degeneration: an animal model for spinal muscular atrophy type III. Hum Mol Genet. 2000 Feb 12;9(3):341-6
1	J:138437 Kariya S, Park GH, Maeno-Hikichi Y, Leykekhman O, Lutz C, Arkovitz MS, Landmesser LT, Monani UR, Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet. 2008 Aug 15;17(16):2552-69
14*	J:154795 Liu H, Shafey D, Moores JN, Kothary R, Neurodevelopmental consequences of Smn depletion in a mouse model of spinal muscular atrophy. J Neurosci Res. 2010 Jan;88(1):111-22
1*	J:159448 Mende Y, Jakubik M, Riessland M, Schoenen F, Rossbach K, Kleinridders A, Kohler C, Buch T, Wirth B, Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Hum Mol Genet. 2010 Jun 1;19(11):2154-67
3	J:307667 Sansa A, de la Fuente S, Comella JX, Garcera A, Soler RM, Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons. Neurobiol Dis. 2021 Jul;155:105366
1	J:70593 Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, Rossire JJ, Chan EK, Lafarga M, Conlon RA, Matera AG, Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. J Cell Biol. 2001 Jul 23;154(2):293-307
3*	J:38576 Viollet L, Bertrandy S, Bueno Brunialti AL, Lefebvre S, Burlet P, Clermont O, Cruaud C, Guenet JL, Munnich A, Melki J, cDNA isolation, expression, and chromosomal localization of the mouse survival motor neuron gene (Smn). Genomics. 1997 Feb 15;40(1):185-8