Gene Expression Literature Summary

• Symbol: Vhl
• Name: von Hippel-Lindau tumor suppressor
• ID: MGI:103223

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	2				1					1			1
In situ RNA (section)	3	1	1	1				1		1		1
Western blot							1				1		2
RT-PCR						2			1				2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Vhl  von Hippel-Lindau tumor suppressor   (Synonyms: pVHL, Vhlh)
Results	Reference
1	J:276713 Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, Goetzman ES, Sims-Lucas S, Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation. J Am Soc Nephrol. 2019 Jul;30(7):1192-1205
3*	J:42486 Gnarra JR, Ward JM, Porter FD, Wagner JR, Devor DE, Grinberg A , Emmert-Buck MR , Westphal H , Klausner RD , Linehan WM, Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9102-7
3*	J:52877 Hemberger M, Himmelbauer H, Neumann HP, Plate KH, Schwarzkopf G , Fundele R, Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in fetal and adult mouse tissues. Hum Mol Genet. 1999 Feb;8(2):229-36
3*	J:26614 Kessler PM, Vasavada SP, Rackley RR, Stackhouse T, Duh FM, Latif F, Lerman MI, Zbar B, Williams BR, Expression of the Von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis. Mol Med. 1995 May;1(4):457-66
3	J:160163 Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H, von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development. 2010 May;137(9):1563-71
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
1	J:214967 Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E, Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 1;393(1):124-36
1	J:237617 Menendez-Montes I, Escobar B, Palacios B, Gomez MJ, Izquierdo-Garcia JL, Flores L, Jimenez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S, Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Dev Cell. 2016 Dec 19;39(6):724-739
2	J:160375 Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS, VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol. 2010 May;176(5):2269-82
3*	J:218695 Soggia A, Ramond C, Akiyama H, Scharfmann R, Duvillie B, von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-alpha and VEGF-A upregulation. Diabetologia. 2014 Nov;57(11):2348-56
1*	J:58075 Voss AK, Thomas T, Gruss P, Mice lacking HSP90beta fail to develop a placental labyrinth. Development. 2000 Jan;127(1):1-11
1	J:228857 Zhu X, Wang F, Zhao Y, Yang P, Chen J, Sun H, Liu L, Li W, Pan L, Guo Y, Kou Z, Zhang Y, Zhou C, He J, Zhang X, Li J, Han W, Li J, Liu G, Gao S, Yang Z, A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. PLoS Genet. 2014 Oct;10(10):e1004589