Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; nervous system development; and regulation of synapse assembly. Acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT and regulation of immune response. Located in synapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in coronary artery disease; diabetes mellitus; hypertension; and type 2 diabetes mellitus. Orthologous to human PTPRD (protein tyrosine phosphatase receptor type D).