Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and positive regulation of the force of heart contraction. Acts upstream of or within several processes, including positive regulation of transcription by RNA polymerase II; regulation of metal ion transport; and striated muscle contraction. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; and cystic fibrosis. Orthologous to human NOS1 (nitric oxide synthase 1).