Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including actin binding activity; beta-catenin binding activity; and integrin binding activity. Involved in lens fiber cell differentiation. Acts upstream of or within several processes, including hippocampus development; negative regulation of MAPK cascade; and negative regulation of cell population proliferation. Located in several cellular components, including adherens junction; cleavage furrow; and ruffle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study coloboma; otitis media; renal cell carcinoma; and vestibular schwannomatosis. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor).