Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables PH domain binding activity; RNA binding activity; and insulin receptor substrate binding activity. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; and negative regulation of insulin receptor signaling pathway. Located in nucleolus and nucleoplasm. Is active in cornified envelope. Is expressed in several structures, including 1st branchial arch mandibular component; blastocyst; central nervous system; early embryo; and tooth. Orthologous to human NCL (nucleolin).