Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables interleukin-1 binding activity and interleukin-1 receptor activity. Acts upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm. Is expressed in several structures, including gut; pituitary gland; reproductive system; thymus; and trachea. Human ortholog(s) of this gene implicated in aggressive periodontitis; esophageal cancer; lung cancer; and organ system cancer. Orthologous to human IL1R2 (interleukin 1 receptor type 2).