Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables double-stranded DNA binding activity and transcription coregulator activity. Involved in cellular response to interferon-alpha. Acts upstream of or within several processes, including cellular response to interferon-beta; positive regulation of osteoblast differentiation; and regulation of transcription by RNA polymerase II. Located in nuclear inclusion body and nucleolus. Is expressed in esophagus; male reproductive gland or organ; and tibia. Orthologous to several human genes including IFI16 (interferon gamma inducible protein 16).