Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Involved in positive regulation of t-circle formation and t-circle formation. Acts upstream of or within several processes, including DNA metabolic process; UV protection; and determination of adult lifespan. Is active in nucleus. Is expressed in brain; cerebral cortex; and telencephalon. Used to study XFE progeroid syndrome. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit).