Automated description from the Alliance of Genome Resources (Release 5.4.0)
Enables peptidase activity. Acts upstream of or within zymogen activation. Located in extracellular space. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1).