Automated description from the Alliance of Genome Resources (Release 6.0.0)
Enables calmodulin binding activity; glutamate receptor binding activity; and protein serine/threonine kinase activity. Involved in regulation of endocannabinoid signaling pathway and regulation of synaptic vesicle docking. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; positive regulation of cardiac muscle cell apoptotic process; and response to ischemia. Located in mitochondrion and postsynaptic density. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; early embryo; eye; genitourinary system; and nervous system. Used to study autism spectrum disorder and bipolar disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha).
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