Automated description from the Alliance of Genome Resources (Release 6.0.0)
Enables complement component C3b binding activity and heparin binding activity. Predicted to be involved in complement activation; proteolysis; and regulation of complement activation, alternative pathway. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H).