Gene Ontology Classifications

Symbol
Name
ID

Shank1
SH3 and multiple ankyrin repeat domains 1
MGI:3613677

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. A structural constituent of postsynaptic density. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and righting reflex. Acts upstream of with a positive effect on AMPA selective glutamate receptor signaling pathway. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in dendritic spine; excitatory synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex; frontal cortex; neocortex region; organ of Corti; and utricle epithelium. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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