Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables cysteine-type deubiquitinase activity. Involved in negative regulation of inflammatory response; regulation of signal transduction; and sprouting angiogenesis. Located in cytoplasm. Part of LUBAC complex. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in otulipenia and primary immunodeficiency disease. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity).