Gene Ontology Classifications

Symbol
Name
ID

Nlrp2
NLR family, pyrin domain containing 2
MGI:3041206

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Automated description from the Alliance of Genome Resources (Release 9.0.0)

Predicted to enable several functions, including Pyrin domain binding activity; aspartic-type endopeptidase inhibitor activity; and caspase binding activity. Predicted to be involved in regulation of inflammatory response. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including 2-cell stage conceptus; 4-8 cell stage conceptus; blastocyst-stage conceptus; gonad; and morula-stage conceptus. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to several human genes including NLRP2 (NLR family pyrin domain containing 2).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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