Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables nuclear retinoic acid receptor binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator activity. Involved in several processes, including kidney development; negative regulation of fat cell differentiation; and regulation of signal transduction. Acts upstream of or within several processes, including heart morphogenesis; hematopoietic or lymphoid organ development; and lung saccule development. Located in nucleus. Is expressed in several structures, including brain; dorsal root ganglion; limb bud; paraxial mesenchyme; and salivary gland. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1).