Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables 2-(3-amino-3-carboxypropyl)histidine synthase activity. Involved in protein histidyl modification to diphthamide. Acts upstream of or within fibroblast proliferation. Predicted to be located in cell junction and nucleoplasm. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; liver; and lung. Used to study Miller-Dieker lissencephaly syndrome. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 1. Orthologous to human DPH1 (diphthamide biosynthesis 1).