Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables histone methyltransferase activity. Acts upstream of or within with a negative effect on gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; blood; heart; sensory organ; and yolk sac. Used to study dilated cardiomyopathy 1A. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).