Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable identical protein binding activity and voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Is expressed in early conceptus; metanephros; and oocyte. Used to study Bartter disease and Bartter disease type 3. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Orthologous to several human genes including CLCNKB (chloride voltage-gated channel Kb).