Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables actin binding activity; microtubule binding activity; and protein homodimerization activity. Involved in actin filament polymerization. Acts upstream of or within several processes, including autophagosome-lysosome fusion; cytoskeleton organization; and myeloid cell differentiation. Located in cytoplasm and nucleus. Part of ESCRT I complex and filamentous actin. Is active in several cellular components, including cleavage furrow; cytoskeleton; and stereocilia tip-link density. Is expressed in several structures, including alimentary system; brain; gonad; submandibular gland primordium; and vibrissa. Used to study congenital dyserythropoietic anemia. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1. Orthologous to human DIAPH3 (diaphanous related formin 3).