Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA binding activity and ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of axon extension and positive regulation of DNA-templated transcription. Located in PML body; axon; and cytoplasm. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in esophageal cancer and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6).