Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable endopeptidase activator activity and protein-macromolecule adaptor activity. Acts upstream of or within several processes, including chemical synaptic transmission; prepulse inhibition; and proteolysis. Part of gamma-secretase complex. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human APH1B (aph-1 homolog B, gamma-secretase subunit).