Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables ubiquitin protein ligase activity. Involved in negative regulation of inflammatory response to antigenic stimulus; negative regulation of non-canonical NF-kappaB signal transduction; and ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human MKRN2 (makorin ring finger protein 2).