Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables [methionine synthase] reductase activity. Involved in several processes, including S-adenosylmethionine cycle; folic acid metabolic process; and sulfur amino acid metabolic process. Predicted to be located in intermediate filament cytoskeleton and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including gut; neural ectoderm; notochord; optic vesicle; and placenta. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); and homocystinuria. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase).