Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and poly-ADP-D-ribose binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of necroptotic process; and protein import into mitochondrial intermembrane space. Acts upstream of or within neuron apoptotic process and regulation of apoptotic DNA fragmentation. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including cerebral cortex; early embryo; long bone epiphyseal plate; retina; and submandibular gland primordium epithelium. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1).