Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein K48-linked ubiquitination; protein catabolic process; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol; nucleoplasm; and synapse. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216).