Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription by RNA polymerase II; and regulation of apoptotic process. Predicted to act upstream of with a negative effect on regulation of cell cycle. Predicted to act upstream of or within negative regulation of cardiac muscle cell proliferation; positive regulation of DNA-templated transcription; and regulation of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including autopod; brain; sensory organ; tooth; and vibrissa. Used to study otitis media. Human ortholog(s) of this gene implicated in several diseases, including Epstein-Barr virus infectious disease; cervical cancer; colorectal cancer; kidney cancer (multiple); and lung cancer (multiple). Orthologous to human TP73 (tumor protein p73).

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Gene Ontology Evidence Code Abbreviations:

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