Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable double-stranded DNA binding activity. Acts upstream of or within female gamete generation and homologous chromosome pairing at meiosis. Located in synaptonemal complex. Is expressed in several structures, including heart; liver; lung; spleen; and testis. Used to study primary ovarian insufficiency 13. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure. Orthologous to human MSH5 (mutS homolog 5).